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Double Metal Cyanides as Efficient Solid Acid Catalysts for Synthesis of β-Amino Alcohols Under Solvent-Free Conditions

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Abstract

A novel application of Fe–Zn double metal cyanide complexes as solid, acid catalysts for regioselective synthesis of β-amino alcohols under solvent-free conditions via ring-opening of epoxides with amines is reported for the first time. The conversion of epoxides to β-amino alcohols is nearly 100%. In the reaction with styrene oxide, regioselective β-amino alcohol formation is higher with aromatic than with aliphatic amines. Strong Lewis acidic Zn2+ ions in the catalyst are probably the active sites in this reaction.

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Acknowledgment

L.S. and J.K.S. acknowledge the Council of Scientific and Industrial Research (CSIR), New Delhi for the award of a research fellowship.

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Authors and Affiliations

  1. National Chemical Laboratory, Pune, 411 008, India

    L. Saikia, J. K. Satyarthi, R. Gonnade, D. Srinivas & P. Ratnasamy

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  1. L. Saikia
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  2. J. K. Satyarthi
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  3. R. Gonnade
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  4. D. Srinivas
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  5. P. Ratnasamy
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Correspondence to D. Srinivas or P. Ratnasamy.

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Saikia, L., Satyarthi, J.K., Gonnade, R. et al. Double Metal Cyanides as Efficient Solid Acid Catalysts for Synthesis of β-Amino Alcohols Under Solvent-Free Conditions. Catal Lett 123, 24–31 (2008). https://doi.org/10.1007/s10562-008-9410-z

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  • DOI: https://doi.org/10.1007/s10562-008-9410-z

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