Factors associated with blood cord unit bankability: an analysis of a 15-year-long case series

Abstract

Blood banking is a long and complex process requiring an accurate screening of potential donors and high-quality control systems. Previous studies in literature investigated factors potentially determining a higher cell levels with the aim of optimizing donors’ selection and improving banking process. This study aims to identify factors associated with the concentration of stem cells in umbilical cord blood, so increasing the probability of bankability, focusing on the possible implications in terms of obstetric and resources management. This is a retrospective study conducted in the Obstetric Units of two Italian Hospitals in Montebelluna and Castelfranco Veneto. Study has been conducted on cord blood units banked between 1999 and 2015. Data on medical histories and clinical characteristics of mother and baby have been retrieved via a retrospective examination of medical records. A total of 869 cord blood units were studied. At multivariable analysis, in agreement with literature, birthweight and placental weight have been found to be associated with higher concentration of total nucleated cells. As additional factor, amount of fluid infused was associated with cord blood units’ count. This study is the first one to clearly identify the role of fluid infusion on cord blood units’ counts in addition to placental weight and delivery. Some non-modifiable features can help in predicting bankability from pre-natal aspects to factors more related with obstetric management is suggested.

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Acknowledgements

We are grateful to all the midwives of the Centers for the work of recruitment and for the collection of the cord blood units, the entire staff of the Cord Blood for the processing, and preservation of the umbilical cord blood. We thank the families of the donors for the altruistic choice to donate the cord blood.

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Correspondence to Dario Gregori.

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Di Tullio, I., Azzolina, D., Piras, G.N. et al. Factors associated with blood cord unit bankability: an analysis of a 15-year-long case series. Cell Tissue Bank 21, 77–87 (2020). https://doi.org/10.1007/s10561-019-09799-y

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Keywords

  • Obstetric management
  • Cord blood banking
  • Haemodilution
  • Bankability
  • Risk-based management