Gender differential in inclination to donate brain for research among Nigerians: the IBADAN Brain Bank Project

Abstract

Background

Laboratory-based studies of neurological disease patterns and mechanisms are sparse in sub-Saharan Africa. However, availability of human brain tissue resource depends on willingness towards brain donation. This study evaluated the level of willingness among outpatient clinic attendees in a Nigerian teaching hospital.

Methods

Under the auspices of the IBADAN Brain Bank Project, a 43—item semi-structured interviewer—administered questionnaire was designed to evaluate knowledge, attitude, and beliefs of individuals attending Neurology, Psychiatry and Geriatrics Outpatient clinics regarding willingness to donate brain for research. Association between participants characteristics and willingness towards brain donation was investigated using logistic regression models. Analysis was conducted using Stata SE version 12.0.

Results

A total of 412 participants were interviewed. Their mean age was 46.3 (16.1) years. 229 (55.6%) were females and 92.5% had at least 6 years of formal education. Overall, 109 (26.7%) were willing to donate brains for research. In analyses adjusting for educational status, religion, ethnicity, marital status and family setting, male sex showed independent association with willingness towards brain donation OR (95% CI) 1.7 (1.08–2.69), p = 0.023. Participants suggested public engagement and education through mass media (including social media) and involvement of religious and community leaders as important interventions to improve awareness and willingness towards brain donation.

Conclusion

The survey revealed low willingness among outpatient clinic attendees to donate brain for research, although men were more inclined to donate. It is imperative to institute public engagement and educational interventions in order to improve consent for brain donation for research.

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References

  1. Adekson MO (2016) Similarities and Differences Between Yoruba Traditional Healers (YTH) and Native American and Canadian Healers (NACH). J Relig Health 55:1717–1728

    Article  PubMed  Google Scholar 

  2. Akinyemi RO et al (2014) Contribution of noncommunicable diseases to medical admissions of elderly adults in Africa: a prospective, cross-sectional study in Nigeria, Sudan, and Tanzania. J Am Geriatr Soc 62:1460–1466

    Article  PubMed  Google Scholar 

  3. Akinyemi RO et al (2018a) Biobanking in a challenging African environment: unique experience from the SIREN Project. Biopreserv Biobank. https://doi.org/10.1089/bio.2017.0113

    Article  PubMed  PubMed Central  Google Scholar 

  4. Akinyemi RO et al (2018b) Brain banking in low—and middle—income countries: Raison D’etre for the Ibadan Brain Ageing, Dementia and Neurodegeneration (IBADAN) Brain Bank Project. Brain Res Bull 145:136–141

    Article  PubMed  Google Scholar 

  5. Allan LM et al (2011) Long term incidence of dementia, predictors of mortality and pathological diagnosis in older stroke survivors. Brain 134:3716–3727

    Article  PubMed  Google Scholar 

  6. Arulogun OS et al (2016) Experience of using an interdisciplinary task force to develop a culturally sensitive multipronged tool to improve stroke outcomes in Nigeria. eNeurologicalSci 4:10–14

    Article  PubMed  PubMed Central  Google Scholar 

  7. Barnes LL et al (2015) Mixed pathology is more likely in black than white decedents with Alzheimer dementia. Neurology 85:528–534

    Article  PubMed  PubMed Central  Google Scholar 

  8. Bennett DA et al (2006a) Neuropathology of older persons without cognitive impairment from two community-based studies. Neurology 66:1837–1844

    Article  CAS  PubMed  Google Scholar 

  9. Bennett DA, Schneider JA, Tang Y, Arnold SE, Wilson RS (2006b) The effect of social networks on the relation between Alzheimer’s disease pathology and level of cognitive function in old people: a longitudinal cohort study. Lancet Neurol 5:406–412

    Article  PubMed  Google Scholar 

  10. Boise L, Hinton L, Rosen HJ, Ruhl M (2017a) Will my soul go to heaven if they take my brain? Beliefs and worries about brain donation among four ethnic groups. Gerontologist 57:719–734

    PubMed  Google Scholar 

  11. Boise L et al (2017b) Willingness to be a brain donor: a survey of research volunteers from 4 racial/ethnic groups. Alzheimer Dis Assoc Disord 31:135–140

    Article  PubMed  PubMed Central  Google Scholar 

  12. Dotchin CL, Akinyemi RO, Gray WK, Walker RW (2013) Geriatric medicine: services and training in Africa. Age Ageing 42:124–128

    Article  PubMed  Google Scholar 

  13. Hewitt RE (2011) Biobanking: the foundation of personalized medicine. Curr Opin Oncol 23:112–119

    Article  PubMed  Google Scholar 

  14. Hurst S et al (2015) Pretesting qualitative data collection procedures to facilitate methodological adherence and team building in Nigeria. Int J Qual Methods 14:53–64

    Article  PubMed  PubMed Central  Google Scholar 

  15. Imam I, Akinyemi R (2016) Nigeria. Pract Neurol 16:75–77

    Article  PubMed  Google Scholar 

  16. Jefferson AL, Lambe S, Cook E, Pimontel M, Palmisano J, Chaisson C (2011) Factors associated with African American and White elders’ participation in a brain donation program. Alzheimer Dis Assoc Disord 25:11–16

    Article  PubMed  PubMed Central  Google Scholar 

  17. Jefferson AL, Lambe S, Romano RR, Liu D, Islam F, Kowall N (2013) An intervention to enhance Alzheimer’s disease clinical research participation among older African Americans. J Alzheimers Dis 36:597–606

    Article  PubMed  PubMed Central  Google Scholar 

  18. Jenkins C et al (2016) Stroke investigative research and education network: community engagement and outreach within phenomics core. Health Educ Behav 43:82S–92S

    Article  PubMed  PubMed Central  Google Scholar 

  19. Kalaria RN et al (2008) Alzheimer’s disease and vascular dementia in developing countries: prevalence, management, and risk factors. Lancet Neurol 7:812–826

    Article  PubMed  PubMed Central  Google Scholar 

  20. Kretzschmar H (2009) Brain banking: opportunities, challenges and meaning for the future. Nat Rev Neurosci 10:70–78

    Article  CAS  PubMed  Google Scholar 

  21. Lambe S, Cantwell N, Islam F, Horvath K, Jefferson AL (2011) Perceptions, knowledge, incentives, and barriers of brain donation among African American elders enrolled in an Alzheimer’s research program. Gerontologist 51:28–38

    Article  PubMed  Google Scholar 

  22. Moodley K, Singh S (2016) “It’s all about trust”: reflections of researchers on the complexity and controversy surrounding biobanking in South Africa. BMC Med Ethics 17:57

    Article  PubMed  PubMed Central  Google Scholar 

  23. Oluwasola OA, Fawole OI, Otegbayo AJ, Ogun GO, Adebamowo CA, Bamigboye AE (2009) The autopsy: knowledge, attitude, and perceptions of doctors and relatives of the deceased. Arch Pathol Lab Med 133:78–82

    PubMed  Google Scholar 

  24. Osuntokun BO (1975) The traditional basis of neuropsychiatric practice among the Yorubas of Nigeria. Trop Geogr Med 27:422–430

    CAS  PubMed  Google Scholar 

  25. Sarfo FS et al (2016) Phone-based Intervention under Nurse Guidance after Stroke (PINGS): study protocol for a randomized controlled trial. Trials 17:436

    Article  PubMed  PubMed Central  Google Scholar 

  26. Wells K, Miranda J, Bruce ML, Alegria M, Wallerstein N (2004) Bridging community intervention and mental health services research. Am J Psychiatry 161:955–963

    Article  PubMed  Google Scholar 

  27. Wight D, Wimbush E, Jepson R, Doi L (2016) Six steps in quality intervention development (6SQuID). J Epidemiol Community Health 70:520–525

    Article  PubMed  Google Scholar 

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Acknowledgements

The IBADAN Brain Bank Project is supported by Grant CTR16A012 from the College of Medicine, University of Ibadan, Nigeria while the African Neurobiobank ELSI Project, the SIREN Study and the Systematic Investigation of Blacks with Stroke using Genomics (SIBS Genomics) Study are supported by Grants U01HG010273, U54HG007479 and R01NS107900 respectively from the National Institutes of Health (NIH) as part of the H3Africa Consortium. RA is further supported by an IBRO Return Home Fellowship Grant. RNK acknowledges the support of the Medical Research Council, UK (G1100540) to the Newcastle Brain Tissue Resource (NBTR).

Funding

Funding

This study was funded by Grant CTR16A012 from the College of Medicine, University of Ibadan, Ibadan, Nigeria.

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Correspondence to Rufus Akinyemi.

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All the authors declare no conflict of interest.

Ethical approval

All procedures performed involving human participants in this study were in accordance with the ethical standards of the University of Ibadan/University College Hospital Institutional Review Committee in Ibadan, Nigeria and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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Informed consent was obtained from all individual participants included in the study.

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Akinyemi, R., Ojagbemi, A., Akinyemi, J. et al. Gender differential in inclination to donate brain for research among Nigerians: the IBADAN Brain Bank Project. Cell Tissue Bank 20, 297–306 (2019). https://doi.org/10.1007/s10561-019-09769-4

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Keywords

  • Willingness
  • Brain donation
  • Brain banking
  • Nigeria
  • Africa
  • LMIC