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Adipose-derived mesenchymal stem cell exosomes: a novel pathway for tissues repair

  • Yuan Fang
  • Yufang Zhang
  • Jianda ZhouEmail author
  • Ke CaoEmail author
Mini Review
  • 319 Downloads

Abstract

The well-characterized curative effect of transplanted mesenchymal stem cells has been mainly attributed to their homing and subsequent differentiation for the repair and regeneration of damaged tissue. Adipose-derived mesenchymal stem cells (ADMSCs) are not only multipotent and plastic, but also abundant as they can be easily harvested with minimally invasive surgical techniques. This makes ADMSCs conducive for clinical applications. Recently, the secretory function of ADMSCs has been regarded as the primary mediator of MSC-based therapy. Exosomes are one kind of small cell extracellular membrane vesicles, which are primarily used to deliver cell-specific proteins, as well as nucleic acids secreted by various cell types. This review will introduce and characterize exosomes-derived ADMSCs (ADMSCs-Exo) and look at new therapies and prospective, including the limitations and outlook for therapeutic strategy. We will describe the latest research progress on myocardial repair, neuroprotection and neurotrophic effects, hepatic repair, renal repair, cutaneous repair, regeneration and other aspects using these cells.

Keywords

Adipose-derived mesenchymal stem cell Exosomes Tissues repair mechanism 

Notes

Compliance with ethical standards

Ethical approval

This article does not contain any studies with human participants or animals performed by any of the authors.

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Copyright information

© Springer Nature B.V. 2019

Authors and Affiliations

  1. 1.The Third Xiangya Hospital of Central South UniversityChangshaPeople’s Republic of China
  2. 2.Anyang Tumor HospitalAnyangPeople’s Republic of China

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