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Organization model for allotransplantations of cryopreserved vascular grafts in Czech Republic

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Abstract

The transplantation of fresh or cryopreserved vascular allografts in patients with a prosthetic graft infection or critical limb ischemia is necessary for their limb salvage and, in many cases, represents a lifesaving procedure. While transplantation of fresh allografts has a long history in the Czech Republic, the standard use of cryopreserved vascular allografts was introduced into the clinical practice in 2011 as a result of the implementation of EU Directive 2004/23/EC into national legislation (Human Cell and Tissue Act No. 296/2008 Coll.). The authors present an organizational model based on cooperation between the majority of Czech Transplant Centers with a tissue establishment licensed by the national competent authority. In various points, we are addressing individual aspects of experimental and clinical studies which affect clinical practice. Based on experimental and clinical work, the first validation of cryopreserved arterial and venous grafts for clinical use was performed between 2011 and 2013. The growing number of centers participating in this programme led to a growing number of patients who underwent transplantation of vascular allografts. In 2015 the numbers of transplanted fresh versus cryopreserved allografts in the Czech Republic were almost equal. Cooperation of the participating centers in the Czech Republic with the licensed Tissue Establishment made it possible to achieve a full compliance with the European Union Directives, and harmonized national legal norms and assured a high quality of cryopreserved vascular allografts.

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Authors and Affiliations

  1. 2nd Department of Surgery - Department of Cardiovascular Surgery, First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague, Prague, Czech Republic

    Miroslav Špaček, Petr Mitáš, Rudolf Špunda & Jaroslav Lindner

  2. Tissue Bank, University Hospital Hradec Králové, Hradec Králové, Czech Republic

    Pavel Měřička

  3. Department of Transplant Surgery, Institute for Clinical and Experimental Medicine, Prague, Czech Republic

    Libor Janoušek & Filip Thieme

  4. Department of Vascular Surgery, Na Homolce Hospital, Prague, Czech Republic

    Petr Štádler

  5. 2nd Department of Surgery, St. Anne’s University Hospital, Faculty of Medicine, Masaryk University, Brno, Czech Republic

    Robert Vlachovský & Robert Staffa

  6. Department of Surgery, University Hospital and Faculty of Medicine Hradec Kralove, Charles University in Prague, Hradec Kralove, Czech Republic

    Igor Guňka

  7. Transplant Center, University Hospital and Faculty of Medicine Hradec Kralove, Charles University in Prague, Hradec Kralove, Czech Republic

    Igor Guňka & Pavel Navrátil

  8. Center of Cardiovascular Surgery and Transplantations Brno, Brno, Czech Republic

    Petr Němec

  9. Department of Transplantation and Tissue Bank, University Hospital Motol, Prague, Czech Republic

    Jaroslav Špatenka

  10. Transplants Coordinating Centre, Prague, Czech Republic

    Miloš Adamec

Authors
  1. Miroslav Špaček
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  2. Pavel Měřička
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  3. Libor Janoušek
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  4. Petr Štádler
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  5. Miloš Adamec
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  6. Robert Vlachovský
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  7. Igor Guňka
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  8. Pavel Navrátil
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  9. Filip Thieme
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  10. Petr Mitáš
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  11. Rudolf Špunda
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  12. Jaroslav Špatenka
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  13. Robert Staffa
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  14. Petr Němec
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  15. Jaroslav Lindner
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Correspondence to Miroslav Špaček.

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Špaček, M., Měřička, P., Janoušek, L. et al. Organization model for allotransplantations of cryopreserved vascular grafts in Czech Republic. Cell Tissue Bank 19, 437–445 (2018). https://doi.org/10.1007/s10561-018-9691-4

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  • DOI: https://doi.org/10.1007/s10561-018-9691-4

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