Stem cell regenerative potential for plastic and reconstructive surgery
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Stem cells represent heterogeneous population of undifferentiated cells with unique characteristics of long term self renewal and plasticity. Moreover, they are capable of active migration to diseased tissues, secretion of different bioactive molecules, and they have immunosuppressive potential as well. They occur in all tissues through life and are involved in process of embryogenesis and regeneration. During last decades stem cells attracted significant attention in each field of medicine, including plastic and reconstructive surgery. The main goal of the present review article is to present and discuss the potential of stem cells and to provide information about their safe utilization in chronic wounds and fistulae healing, scar management, breast reconstruction, as well as in bone, tendon and peripheral nerve regeneration.
KeywordsStem cells iPSCs Regenerative medicine Plastic surgery
Received from Ministry of Health of the Slovak republic (Registration number: 2012/4-UKBA-4) and Slovak Research and Development Agency (Registration number: APVV-14-0032).
MB designed, organized, and prepared the manuscript from the initial draft to final version. MC participated in manuscript preparation. IK participated in manuscript preparation. RZ was involved in manuscript design, organization and preparation. JF participated in manuscript preparation. JK participated in manuscript preparation.
Compliance with ethical standards
Conflict of interest
All authors have completed the Unified Competing Interest form at www.icmje.org/coi_disclosure.pdf (available on request from the corresponding author) and declare: no support from any organization for the submitted work; no financial relationships with any organizations that might have an interest in the submitted work in the previous 3 years; no other relationships or activities that could appear to have influenced the submitted work.
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