Cell and Tissue Banking

, Volume 17, Issue 4, pp 653–663 | Cite as

Liver diseases: what is known so far about the therapy with human amniotic membrane?

  • Sara Guerra
  • Ana Catarina MamedeEmail author
  • Maria João Carvalho
  • Mafalda Laranjo
  • José Guilherme Tralhão
  • Ana Margarida Abrantes
  • Cláudio Jorge Maia
  • Maria Filomena Botelho
Full Length Review


Liver, the largest intern organ of the human body, is responsible for several vital tasks such as digestive and excretory functions, as well as for nutrients storage and metabolic functions, synthesis of new molecules and purification of toxic chemicals. Cirrhosis, fibrosis and hepatocellular carcinoma are the most prevalent liver diseases. Despite all the studies performed so far, treatment options for these diseases are very limited. For this reason, it is urgent to find effective therapies for these pathologies. Several studies have been performed during the last decade about the possible application of human amniotic membrane in hepatic diseases therapy. Promising results about human amniotic membrane or its derived cells, in vitro and in vivo, applications in fibrosis, cirrhosis and hepatocellular carcinoma were already published. Since it is an attractive study area, it is becoming a dynamic scientific subject. However, the action mechanisms of human amniotic membrane and its derived cells in hepatic diseases therapy must be precisely known in order that this promising therapy could be clinically used.


Liver diseases Fibrosis Cirrhosis Hepatocellular carcinoma Human amniotic membrane 



Ana Catarina Mamede (SFRH/BD/73649/2010) and Maria João Carvalho (SFRH/SINTD/60068/2009) wishes to thank to Portuguese Foundation for Science and Technology for their PhD Grants.

Compliance with ethical standards

Conflicts of interest

The authors declare that they have no conflicts of interest.


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Copyright information

© Springer Science+Business Media Dordrecht 2016

Authors and Affiliations

  • Sara Guerra
    • 1
  • Ana Catarina Mamede
    • 1
    • 2
    • 3
    • 4
    Email author
  • Maria João Carvalho
    • 1
    • 3
    • 4
    • 5
  • Mafalda Laranjo
    • 1
    • 3
    • 4
  • José Guilherme Tralhão
    • 1
    • 3
    • 6
  • Ana Margarida Abrantes
    • 1
    • 3
    • 4
  • Cláudio Jorge Maia
    • 2
  • Maria Filomena Botelho
    • 1
    • 3
    • 4
  1. 1.Biophysics Unit, Faculty of MedicineUniversity of CoimbraCoimbraPortugal
  2. 2.CICS-UBI, Health Sciences Research CentreUniversity of Beira InteriorCovilhãPortugal
  3. 3.CIMAGO, Faculty of MedicineUniversity of CoimbraCoimbraPortugal
  4. 4.CNC.IBILIUniversity of CoimbraCoimbraPortugal
  5. 5.Obstetrics ServiceCoimbra Hospital and University CentreCoimbraPortugal
  6. 6.Surgical Department ACoimbra Hospital and University CentreCoimbraPortugal

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