The European Association of Tissue Banks (EATB) donor case workshop is a forum held within the program of the EATB annual congress. The workshop offers an opportunity to discuss and evaluate approaches taken to challenging situations regarding donor selection, it promotes consensus development in deciding tissue donor acceptability when donor health issues are not addressed in standards and regulations, and serves to strengthen the professional tissue banking networks across Europe and beyond. This report reflects some of the discussion at the workshop during the annual congress in Vienna in 2012. The cases presented dealt with problems encountered by tissue bank facilities concerning idiopathic thrombocytopenia and auto-immune disorders, hemodilution and blood sample identification, premalignant and malignant lesions, and Huntington’s disease. The discussions during the workshop demonstrate that the implications on the safety of tissue transplantation of various tissue donor illnesses, physical findings and behaviours, and the preventive measures taken by tissue facilities, may not always be agreed by tissue facility medical directors and other professionals. Moreover, they reveal that operating procedures, regulations and standards cannot comprehensively cover all tissue donor findings, medical histories and circumstances surrounding the cause of death. For many of the issues raised, there is a need for scientific research to provide a better evidence base for future deliberations about the suitability and eligibility of tissue allograft donors.
This is a preview of subscription content, log in to check access.
Buy single article
Instant access to the full article PDF.
Price includes VAT for USA
Subscribe to journal
Immediate online access to all issues from 2019. Subscription will auto renew annually.
This is the net price. Taxes to be calculated in checkout.
American Association of Tissue Banking (2012) Standards for tissue banking, http://www.aatb.org. Assessed 30 April 2013
Beele H, Van Wijk M, Bokhorst A, Van Geyt C (2009) Physical examination of the potential tissue donor; what does literature tell us. Cell Tissue Bank 10:253–257
Commission Directive 2006/17/EC (2006) Technical requirements for the donation, procurement and testing of human tissues and cells
Cox M, Brubaker SA (2012) Chapter 1: Regulations and standards. In: Fehily D, Brubaker SA, Kearney JN, Wolfinbarger L (eds) Tissue and cell processing: an essential guide. Wiley Blackwell Publishing, Hoboken, pp 1–26. ISBN 978-1-4051-9826-4
Eastlund T, Warwick RM (2012) Chapter 4: Diseases transmitted by transplantation of organs, tissues, and cells. In: Ruth R, Warwick M, Brubaker SA (eds) Tissue and cell use: an essential guide. Wiley Blackwell Publishing, Hoboken, pp 72–113. ISBN 978-1-4051-9825-7
Gartner HV, Seidl C, Luckenbach C et al (1996) Genetic analysis of a sarcoma accidentally transplanted from a patient to a surgeaon. N Engl J Med 335:1494–1497
Gugel EA, Sanders ME (1986) Needle-stick transmission of human colonic adenocarcinoma. N Engl J Med 315:1487
Mosby (2009) Mosby’s medical dictionary, 8th edn. Elsevier, Amsterdam
Palmer SH, Gibbons CL, Athanasou NA (1999) The pathology of bone allograft. J Bone Joint Surg 81:333–335
Richters CD, Van Wijk M, Beele H (2012) The risk of transmission of malignant and premalignant skin lesions through tissue transplantation. Abstract book of the 21st. Annual Congress of the European Association of Tissue Banks
Sabbele NR, Van Oudenaren A, Hooijkaas H, Benner R (1987) The effect of corticosteroids upon murine B cells in vivo and in vitro as determined in the LPS-culture system. Immunology 62:285–290
Saegeman VSM, Chandrasekar A, Vanwijck M, Beele H, Montenero M, Navarro A, Van Geyt C, Bokhorst AG, Fehily D, Warwick RM (2009) EATB donor case workshop 2007. Cell Tissue Bank 10:351–357
Sugihara S, van Ginkel AD, Jiya TU, van Royen BJ, van Diest PJ, Wuisman PIJM (1999) Histopathology of retrieved allografts of the femoral head. J Bone Joint Surg Br 81B:336–341
UK Blood Transfusion and Transplant Services (2005) Donor selection guidelines for deceased tissue donors in Guidelines for the blood transfusion services in the United Kingdom chapter 22 (Tissue banking: selection of donors), 7th edition. http://www.transfusionguidelines.org.uk/index.aspx?Publication=CT. Accessed 18 Feb 2013
U.K. National Health Services (2013) Gov. Height/weight chart. In: NHS choices. LiveWell section. http://www.nhs.uk/Livewell/healthy-living/Pages/height-weight-chart.aspx. Accessed 2 May 2013
U.S. Department of Health and Human Services Food and Drug Administration Center for Biologics (2007) Evaluation and research guidance for industry: eligibility determination for donors of human cells, tissues, and cellular and tissue-based products. (Appendices 1, 2, and 3)
Van Wijk MJ, Fehily D, Brubaker SA, Eastlund T, Kurz J, Parker R, Beele H, Herson MR, Monig HJ, Chandrasekar A, Holovska V, Wysocka-Wycisk A, Brown MS, Wistanley E, Sanchez-Ibanez J, Warwick RM (2012) Results of the clinical donor case and quality system case workshops of the European Association of Tissue Banks annual meeting 2009. Cell and Tissue Bank 13:191–202. doi:10.1007/s10561-011-9263-3
Warwick RM, Rushambuza FG, Brown J, Patel R, Tabb S, Poniatowski S, Ranson JA, Brown CJ (2008) Confirmation of cadaveric blood sample identity by DNA profiling using STR (short tandem repeat) analysis. Cell Tissue Bank 9(4):323–328. doi:10.1007/s10561-008-9071-6
WHO project Notify Library http://www.notifylibrary.org/notifylibrary/search/incident. Accessed 30 April 2013
Zwitser EW, de Gast A, Basie MJ, van Kemenade FJ, van Royen BJ (2009) B-cell lymphoma in retrieved femoral heads: a long term follow up. BMC Musculoskelet Disord 10:53–58
Robert Parker: Heart Valve Bank, Royal Brompton Hospital, London, UK (retired).
About this article
Cite this article
Beele, H., van Wijk, M.J., Parker, R. et al. Report of the clinical donor case workshop of the European Association of Tissue Banks annual meeting 2012. Cell Tissue Bank 14, 561–570 (2013). https://doi.org/10.1007/s10561-013-9400-2
- Tissue donor selection
- Tissue donor suitability
- Disease transmission
- Tissue transplantation
- Idiopathic thrombocytopenia
- Huntington’s disease