Abstract
To investigate the clinical behavior of deep frozen and irradiated bone allografts in the treatment of depressed tibial plateau fractures. Twenty-two patients with a tibial plateau fracture were treated with cancellous bone allografts. The bone allograft preparation process included fresh-freezing at −70 °C for 4 weeks and gamma-irradiation at 25 kGy. All of the patients were followed for 1–2 years. The clinical effects were assessed using the Rasmussen score for tibial head fractures and X-rays. Postoperatively, the average excellent and fair Rasmussen scores were 88.9 %. Only one patient developed an infection, with no integration between allograft and recipient bone observed. All of the other bone allografts were incorporated successfully, and no osteoporosis or sclerosis was observed. The frozen and gamma-irradiated bone allograft is a good alternative in the treatment of tibial plateau fractures, which we have shown can integrate with the surrounding host bone.
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Bowerman JW, Hughes JL (1975) Radiology of bone grafts. Radiol Clin North Am 13:67–77
Buckley SC, Stockley I, Hamer AJ et al (2005) Irradiated allograft bone for acetabular revision surgery. Results at a mean of five years. J Bone Joint Surg Br 87(3): 310–313
Ebraheim NA, Sabry FF, Haman SP (2004) Open reduction and internal fixation of 117 tibial plateau fractures. Orthopedics 27(12):1281–1287
Elves MV (1975) Studies of the behaviour of allogeneic bone grafts in inbred rats. Transplantation 19(5):416–423
Graham SM, Leonidou A, Aslam-Pervez N et al (2010) Biological therapy of bone defects the immunology of bone allo-transplantation. Expert Opin Biol Ther 10(6):885–901
Hannink G, Schreurs BW, Buma P (2007) Irradiation has no effect on the incorporation of impacted morselized bone: a bone chamber study in goats. Acta Orthop 78(1):31–38
Johnson D (2004) AAOS 2004: all about allografts—highlights of the 71st annual meeting of the American Academy of Orthopaedic Surgeons. Med Gen Med 6(4):23
Kayurapan A, Aresanasuwan T, Waikakul S (2009) Decreasing strength of bone allograft after recovery and preservation. J Med Assoc Thai 92(Suppl5):S76–S80
Khan SN, Cammisa FP Jr, Sandhu HS et al (2005) The biology of bone grafting. J Am Acad Orthop Surg 13(1):77–86
Komender J, Marczynski W, Tylman D et al (2001) Preserved tissue allografts in reconstructive surgery. Cell Tissue Bank 2(2):103–112
Lobo Gajiwala A, Agarwal M, Puri A et al (2003) The use of irradiated allografts in reconstruction of tumor defects—the Tata Memorial Hospital experience. Cell Tissue Bank 4(2–4):125–132
Moreau MF, Gallois Y, Basle MF et al (2000) Gamma irradiation of human bone allografts alters medullary lipids and releases toxic compounds for osteoblast-like cells. Biomaterials 21:369–376
Nather A (2004) Musculoskeletal tissue banking in Singapore: 15 years of experience (1988–2003). J Orthop Surg (Hong Kong) 12(2):184–190
Nguyen H, Morgan DA, Forwood MR (2007) Sterilization of allograft bone: effects of gamma irradiation on allograft biology and biomechanics. Cell Tissue Bank 8(2):93–105
Rasmussen PS (1973) Tibial condylar fractures: impairment of knee joint stability as an indication for surgical treatment. J Bone Joint Surg 55A:1331–1350
Reikerås O, Sigurdsen UW, Shegarfi H (2010) Impact of freezing on immunology and incorporation of bone allograft. J Orthop Res 28(9):1215–1219
Sauer HD, Schoettle H (1979) The stability of osteosyntheses bridging defects. Arch Orthop Trauma Surg 95(1–2):27–30
Smith RA, Ingels J, Lochemes JJ et al (2001) Gamma irradiation of HIV-1. J Orthop Res 19:815–819
Tscherne H, Lobenhoffer P (1993) Tibial plateau fractures. Management and expected results. Clin Orthop Relat Res 292:87–100
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Feng, W., Fu, L., Liu, J. et al. The use of deep frozen and irradiated bone allografts in the reconstruction of tibial plateau fractures. Cell Tissue Bank 14, 375–380 (2013). https://doi.org/10.1007/s10561-012-9342-0
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DOI: https://doi.org/10.1007/s10561-012-9342-0