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Seroprevalence of human T lymphtropic virus (HTLV) among tissue donors in Iranian tissue bank

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Abstract

Iranian Tissue Bank prepares a wide range of human tissue homografts such as; heart valve, bone, skin, amniotic membrane and other tissues for different clinical applications. The purpose of this study was to determine the seroprevalence of HTLV in tissue donors. About 1,548 tissue donors were studied during a 5-years period by ELISA assays. HTLV1,2—antibodies were tested for all of donors with other tests upon American Association of Tissue Banks (AATB) standards. About 25 (1.61%) out of 1,548 tissue donors were HTLV positive that 17 donors were male and 8 were female (female/male ratio was approximately 47%). Regarding to the prevalence of HTLV among tissue donors and importance of cell and tissue safety and quality assurance, we recommend that all blood, cell and tissue banks should be involved both routine serological methods and other complementary tests such as polymerase chain reaction (PCR) for diagnosis of HTLV.

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Acknowledgments

We would like to acknowledge the Research Deputy of Tehran University of Medical Sciences (TUMS) and Research Deputy of Iranian Tissue Bank. We also thank Farideh Khosravi, Hamideh Gholami, Elham Ravanasa, Azadeh Hossein khani, Maryam Eslami, seyed kazem hosseini, Leila Khatibshad, and all the staff from ITB for helping with data collection.

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Authors and Affiliations

  1. Iranian Tissue Bank Research and Preparation Center & Brain and Spinal Injury Repair Research Center, Tehran University of Medical Sciences, Imam Khomeini Hospital, Keshavarz Blvd., Tehran, Iran

    Babak Arjmand & Seyed Hamidreza Aghayan

  2. Iranian Tissue Bank Research and Preparation Center, Tehran University of Medical Sciences, Imam Khomeini Hospital, Keshavarz Blvd., Tehran, Iran

    Parisa Goodarzi, Mohammad Farzanehkhah, Seyed Mohamadjavad Mortazavi & Mohamad Hossein Niknam

  3. Medical Ethics and History of Medicine Research Center, Tehran University of Medical Sciences, Imam Khomeini Hospital, Keshavarz Blvd., Tehran, Iran

    Ali Jafarian

  4. Faculty of Chemistry, Urmia University, Urmia, Iran

    Farzin Arjmand

  5. Allameh Tabatabaei University, Tehran, Iran

    Soheyla Jebelly far

Authors
  1. Babak Arjmand
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  2. Seyed Hamidreza Aghayan
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  3. Parisa Goodarzi
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  4. Mohammad Farzanehkhah
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  5. Seyed Mohamadjavad Mortazavi
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  6. Mohamad Hossein Niknam
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  7. Ali Jafarian
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  8. Farzin Arjmand
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  9. Soheyla Jebelly far
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Correspondence to Babak Arjmand.

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Arjmand, B., Aghayan, S.H., Goodarzi, P. et al. Seroprevalence of human T lymphtropic virus (HTLV) among tissue donors in Iranian tissue bank. Cell Tissue Bank 10, 247–252 (2009). https://doi.org/10.1007/s10561-008-9117-9

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  • DOI: https://doi.org/10.1007/s10561-008-9117-9

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