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Evaluation of demineralised, freeze-dried, irradiated bone allografts in the treatment of osseous defects in the oral cavity

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Abstract

Demineralised, freeze-dried bone allografts (DFDBA) have been used extensively by dentists in the treatment of periodontal and periapical osseous defects resulting from inflammatory diseases. Their use in India however, is limited by the availability of quality allografts and the high cost of imported alternatives. A study was conducted to assess the osteogenic potential of DFDBA prepared for the first time in India by the Tata Memorial Hospital (TMH) Tissue Bank. The DFDBA was used in the treatment of osseous defects after removal of periapical lesions associated with devitalised teeth in 10 healthy patients. At the 6-month recall visit all the patients showed a remarkable decrease in the grades of mobility, and 9 out of the 10 patients showed radiographic evidence of complete healing of the osseous defects with evidence of normal bony trabaeculae. These findings indicate that the indigenously prepared DFDBA is a cost effective, biocompatible material with osteogenic potential that can be used effectively in treating osseous defects of periapical lesions associated with non vital teeth.

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Authors and Affiliations

  1. Tissue Bank, Tata Memorial Hospital, Dr. Ernest Borges Road, Mumbai, 400 012, India

    Astrid Lobo Gajiwala

  2. Oral and Maxillofacial Surgery, Department of Dentistry, King Edward Memorial Hospital, Mumbai, India

    Basavanthappa Dilip Kumar

  3. Department of Dentistry, King Edward Memorial Hospital, Mumbai, India

    Payal Chokhani

Authors
  1. Astrid Lobo Gajiwala
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  2. Basavanthappa Dilip Kumar
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  3. Payal Chokhani
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Correspondence to Astrid Lobo Gajiwala.

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Lobo Gajiwala, A., Dilip Kumar, B. & Chokhani, P. Evaluation of demineralised, freeze-dried, irradiated bone allografts in the treatment of osseous defects in the oral cavity. Cell Tissue Banking 8, 23–30 (2007). https://doi.org/10.1007/s10561-006-9014-z

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  • DOI: https://doi.org/10.1007/s10561-006-9014-z

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