Skip to main content
Log in

Predicting protein secondary structure based on Bayesian classification procedures on Markovian chains

  • Systems Analysis
  • Published:
Cybernetics and Systems Analysis Aims and scope

Abstract

The paper discusses numerical results of predicting protein secondary structure using Bayesian classification procedures based on nonstationary Markovian chains. A new approach is used, based on the classification of pairs of states for pairs of neighboring amino acids. It improves the prediction accuracy as compared with that of the classification of the state of one amino acid.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. K. Ginalski, N. V. Grishin, A. Godzik, and L. Rychlewski, “Practical lessons from protein structure prediction,” Nucleic Acids Res., 33, 1874–1891 (2005).

    Article  Google Scholar 

  2. J. L. Casti, “Confronting science’s logical limits,” Scientific America, October, 78–81 (1996).

  3. A. V. Finkel’shtein and O. B. Ptitsyn, Physics of Protein: A Course of Lectures, with Color and Stereoscopic Illustrations and Problems [in Russian], KDU, Moscow (2005).

    Google Scholar 

  4. P. Baldi and S. Brunak, Bioinformatics: Machine Learning Approach, MIT Press, Cambridge (2001).

    MATH  Google Scholar 

  5. B. Rost, “Rising accuracy of protein secondary structure prediction,” in: D. Chasman (ed.), Protein Structure Determination, Analysis, and Modeling for Drug Discovery, New York (2003), pp. 207–249.

  6. B. A. Beletskii, S. V. Vasil’ev, and A. M. Gupal, “Predicting protein secondary structure based on Bayesian classification procedures,” Probl. Upravl. Inform., No. 1, 61–69 (2007).

  7. A. M. Gupal, S. V. Pashko, and I. V. Sergienko, “Efficiency of Bayesian classification procedure,” Cybern. Syst. Analysis, 31, No. 4, 543–554 (1995).

    Article  MATH  MathSciNet  Google Scholar 

  8. I. V. Sergienko and A. M. Gupal, “Design principles for inductive inference procedures,” Cybern. Syst. Analysis, 42, No. 4, 51–63 (2006).

    Google Scholar 

  9. B. A. Beletskii, A. A. Vagis, S. V. Vasil’ev, and N. A. Gupal, “The complexity of Bayesian procedure of inductive inference: Discrete case,” Probl. Upravl. Inform., No. 6, 55–70 (2006).

  10. A. M. Gupal, I. I. Andreichuk, A. A. Vagis, and L. A. Zakrevskaya, “Statistical analysis of proteins,” Probl. Upravl. Inform., No. 6, 124–129 (2004).

  11. T. W. Anderson and L. A. Goodman, “Statistical inference about Markov chains,” Ann. Math. Statist., 28, 89–110 (1957).

    MathSciNet  Google Scholar 

  12. http://www.ncbi.nlm.nih.gov/

  13. http://cubic.bioc.columbia.edu/eva/

Download references

Author information

Authors and Affiliations

Authors

Additional information

__________

Translated from Kibernetika i Sistemnyi Analiz, No. 2, pp. 59–64, March–April 2007.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Sergienko, I.V., Beletskii, B.A., Vasil’ev, S.V. et al. Predicting protein secondary structure based on Bayesian classification procedures on Markovian chains. Cybern Syst Anal 43, 208–212 (2007). https://doi.org/10.1007/s10559-007-0039-5

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10559-007-0039-5

Keywords

Navigation