Skip to main content
SpringerLink
Log in

Winding Down the Storm: Could Empagliflozin’s Ion-Dependent Mechanisms Tackle the Ventricular Arrhythmia Burden in Chronic Chagas Cardiomyopathy?

  • Letter to the Editor
  • Published:
Cardiovascular Drugs and Therapy Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1

Data Availability

Not applicable.

Code Availability

Not applicable.

References

  1. Peng X, Li L, Lin R, et al. Empagliflozin ameliorates ouabain-induced Na+ and Ca2+ dysregulations in ventricular myocytes in an Na+-dependent manner. Cardiovasc Drugs Ther. 2023;37:461–9.

    Article  CAS  PubMed  Google Scholar 

  2. Nunes MCP, Beaton A, Acquatella H, et al. Chagas cardiomyopathy: an update of current clinical knowledge and management: a scientific statement from the American Heart Association. Circulation. 2018;138:e169–209.

    Article  PubMed  Google Scholar 

  3. Bögeholz N, Pauls P, Bauer BK, et al. Overexpression of the Na+ /Ca2+ exchanger influences ouabain-mediated spontaneous Ca2+ activity but not positive inotropy. Fundam Clin Pharmacol. 2019;33:43–51.

    Article  PubMed  Google Scholar 

  4. Li H-L, Lip GYH, Feng Q, et al. Sodium-glucose cotransporter 2 inhibitors (SGLT2i) and cardiac arrhythmias: a systematic review and meta-analysis. Cardiovasc Diabetol. 2021;20:100.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Santos-Miranda A, Joviano-Santos JV, Sarmento JO, et al. A novel substrate for arrhythmias in Chagas disease. PLoS Negl Trop Dis. 2021;15:e0009421.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

Funding

The EMPA-Chagas study was funded by Boehringer Ingelheim S.A. (Investigator initiated grant code CorA-680960).

Author information

Authors and Affiliations

  1. Heart Failure and Transplant Clinic, Fundación Cardiovascular de Colombia, Calle 155A # 23-58 Urbanización El Bosque, PO. Box 681001, Floridablanca, Colombia

    Sergio Alejandro Gómez-Ochoa & Luis Eduardo Echeverría

  2. Department of General Internal Medicine and Psychosomatics, Heidelberg University Hospital, Heidelberg, Germany

    Sergio Alejandro Gómez-Ochoa

  3. Research Group and Development of Nursing Knowledge (GIDCEN-FCV), Research Center, Fundación Cardiovascular de Colombia, Calle 155A # 23-58 Urbanización El Bosque, PO. Box 681001, Floridablanca, Colombia

    Lyda Z. Rojas

Authors
  1. Sergio Alejandro Gómez-Ochoa
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Lyda Z. Rojas
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Luis Eduardo Echeverría
    View author publications

    You can also search for this author in PubMed Google Scholar

Contributions

SAGO and LEE designed the research idea, SAGO and LZR performed the preliminary analyses, and all authors participated in drafting the manuscript and its critical revision.

Corresponding author

Correspondence to Luis Eduardo Echeverría.

Ethics declarations

Ethics Approval

The institutional Ethics Committee of the Fundación Cardiovascular de Colombia approved the EMPA-Chagas study (CEI-2023–05269).

Consent to Participate

All patients provided their written informed consent for participation.

Consent for Publication

All authors agree to the publication of the manuscript in its present form.

Competing Interests

SAGO, LZR, and LEE received funding from Boehringer Ingelheim S.A. for the development of the EMPA-Chagas Study.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Gómez-Ochoa, S.A., Rojas, L.Z. & Echeverría, L.E. Winding Down the Storm: Could Empagliflozin’s Ion-Dependent Mechanisms Tackle the Ventricular Arrhythmia Burden in Chronic Chagas Cardiomyopathy?. Cardiovasc Drugs Ther 38, 203–205 (2024). https://doi.org/10.1007/s10557-023-07510-8

Download citation

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10557-023-07510-8

Search

Navigation