Skip to main content
SpringerLink
Log in

Letter to the Editor Regarding “The Role of Combined SGLT1/SGLT2 Inhibition in Reducing the Incidence of Stroke and Myocardial Infarction in Patients with Type 2 Diabetes Mellitus”

  • Letter to the Editor
  • Published:
Cardiovascular Drugs and Therapy Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  1. Pitt B, Steg G, Leiter L A, et al. The role of combined SGLT1/SGLT2 Inhibition in reducing the incidence of stroke and myocardial infarction in patients with type 2 diabetes mellitus [J]. Cardiovascular Drugs Ther. 2021.

  2. Bhatt DL, Szarek M, Pitt B, et al. Sotagliflozin in patients with diabetes and chronic kidney disease [J]. N Engl J Med. 2021;384(2):129–39.

    Article  CAS  Google Scholar 

  3. Bhatt DL, Szarek M, Steg PG, et al. Sotagliflozin in patients with diabetes and recent worsening heart failure [J]. N Engl J Med. 2021;384(2):117–28.

    Article  CAS  Google Scholar 

  4. Zhou L, Cryan EV, D'andrea MR, et al. Human cardiomyocytes express high level of Na+/glucose cotransporter 1 (SGLT1) [J]. J Cell Biochem. 2003;90(2):339–46.

    Article  CAS  Google Scholar 

  5. Rieg T, Masuda T, Gerasimova M, et al. Increase in SGLT1-mediated transport explains renal glucose reabsorption during genetic and pharmacological SGLT2 inhibition in euglycemia [J]. Am J Physiol Renal Physiol. 2014;306(2):F188–93.

    Article  CAS  Google Scholar 

  6. Banerjee SK, Mcgaffin KR, Pastor-Soler NM, et al. SGLT1 is a novel cardiac glucose transporter that is perturbed in disease states [J]. Cardiovasc Res. 2009;84(1):111–8.

    Article  CAS  Google Scholar 

  7. Yoshii A, Nagoshi T, Kashiwagi Y, et al. Cardiac ischemia-reperfusion injury under insulin-resistant conditions: SGLT1 but not SGLT2 plays a compensatory protective role in diet-induced obesity [J]. Cardiovasc Diabetol. 2019;18(1):85.

    Article  Google Scholar 

  8. Kashiwagi Y, Nagoshi T, Yoshino T, et al. Expression of SGLT1 in human hearts and impairment of cardiac glucose uptake by phlorizin during ischemia-reperfusion injury in mice [J]. PLoS One. 2015;10(6):e0130605.

    Article  Google Scholar 

  9. Gorboulev V, Schürmann A, Vallon V, et al. Na(+)-D-glucose cotransporter SGLT1 is pivotal for intestinal glucose absorption and glucose-dependent incretin secretion [J]. Diabetes. 2012;61(1):187–96.

    Article  CAS  Google Scholar 

  10. Matsushita N, Ishida N, Ibi M, et al. Chronic pressure overload induces cardiac hypertrophy and fibrosis via increases in SGLT1 and IL-18 gene expression in mice [J]. Int Heart J. 2018;59(5):1123–33.

    Article  CAS  Google Scholar 

Download references

Funding

This work was supported by the National Natural Science Foundation of China (NSFC 82060080).

Author information

Authors and Affiliations

  1. Department of Cardiovascular Medicine, Lanzhou University Second Hospital, Lanzhou, 730000, China

    Yafei Xie & Xiaowei Zhang

  2. Second Clinical Medical College, Lanzhou University, Lanzhou, 730000, China

    Yafei Xie & Xiaowei Zhang

Authors
  1. Yafei Xie
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Xiaowei Zhang
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Xiaowei Zhang.

Additional information

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Electronic supplementary material

Below is the link to the electronic supplementary material.

(PDF 24.8 KB)

(PDF 24.8 KB)

(PDF 28.6 KB)

(PDF 26.5 KB)

(PDF 26 KB)

(PDF 30.8 KB)

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Xie, Y., Zhang, X. Letter to the Editor Regarding “The Role of Combined SGLT1/SGLT2 Inhibition in Reducing the Incidence of Stroke and Myocardial Infarction in Patients with Type 2 Diabetes Mellitus”. Cardiovasc Drugs Ther 36, 571–572 (2022). https://doi.org/10.1007/s10557-021-07301-z

Download citation

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10557-021-07301-z

Search

Navigation