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Antiplatelet Therapy in Elderly Patients with Acute Coronary Syndromes: the Clopidogrel Revenge: Possible Reasons for a Bright Comeback

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References

  1. De Servi S, Crimi G, Calabrò P, et al. Relationship between diabetes, platelet reactivity, and the SYNTAX score to one-year clinical outcome in patients with non-ST-segment elevation acute coronary syndrome undergoing percutaneous coronary intervention. EuroIntervention. 2016;12:312–8.

  2. Wiviott SD, Braunwald E, McCabe CH, et al. Prasugrel versus clopidogrel in patients with acute coronary syndromes. N Engl J Med. 2007;357:2001–15.

  3. Wallentin L, Becker RC, Budaj A, et al. Ticagrelor versus clopidogrel in patients with acute coronary syndromes. N Engl J Med. 2009;361:1045–57.

  4. Capodanno D, Alfonso F, Levine GN, Valgimigli M, Angiolillo DJ. ACC/AHA versus ESC guidelines on dual antiplatelet therapy: JACC Guideline Comparison. J Am Coll Cardiol. 2018;72:2915–31.

  5. Wiviott SD, Desai N, Murphy SA, et al. Efficacy and safety of intensive antiplatelet therapy with prasugrel from TRITON-TIMI 38 in a core clinical cohort defined by worldwide regulatory agencies. Am J Cardiol. 2011;108:905–11.

  6. Husted S, James S, Becker RC, et al. Ticagrelor versus clopidogrel in elderly patients with acute coronary syndromes: a substudy from the prospective randomized PLATelet inhibition and patient Outcomes (PLATO) trial. Circ Cardiovasc Qual Outcomes. 2012;5:680–8.

  7. Capranzano P, Angiolillo DJ. Tailoring P2Y12 inhibiting therapy in elderly patients with myocardial infarction undergoing primary percutaneous coronary intervention. J Am Heart Assoc. 2019;8:e014000.

  8. Savonitto S, Ferri LA, Piatti L, et al. Comparison of reduced-dose prasugrel and standard-dose clopidogrel in elderly patients with acute coronary syndromes undergoing early percutaneous revascularization. Circulation. 2018;137:2435–45.

  9. Gimbel M, Qaderdan K, Willemsen L, et al. Clopidogrel versus ticagrelor or prasugrel in patients aged 70 years or older with non-ST-elevation acute coronary syndrome (POPular AGE): the randomised, open-label, non-inferiority trial. Lancet. 2020;395:1374–81.

  10. Crimi G, Morici N, Ferrario M, Ferri LA, Piatti L, Grosseto D, et al. Time course of ischemic and bleeding burden in elderly patients with acute coronary syndromes randomized to low-dose prasugrel or clopidogrel. J Am Heart Assoc. 2019;8:e010956G.

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Authors and Affiliations

  1. University of Pavia Medical School, 27100, Pavia, Italy

    Stefano De Servi

  2. IRCCS MultiMedica, Sesto San Giovanni, 20099, Milan, Italy

    Antonio Landi

  3. Division of Cardiology, Manzoni Hospital, Via dell’Eremo, 9, 23900, Lecco, Italy

    Stefano Savonitto

Authors
  1. Stefano De Servi
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  2. Antonio Landi
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  3. Stefano Savonitto
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All authors contributed to the study conception and design.

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Correspondence to Stefano De Servi.

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De Servi, S., Landi, A. & Savonitto, S. Antiplatelet Therapy in Elderly Patients with Acute Coronary Syndromes: the Clopidogrel Revenge: Possible Reasons for a Bright Comeback. Cardiovasc Drugs Ther 35, 399–401 (2021). https://doi.org/10.1007/s10557-020-07055-0

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  • DOI: https://doi.org/10.1007/s10557-020-07055-0

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