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Ultrasound Theranostics in Adult and Pediatric Cardiovascular Research

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Abstract

Theranostics, the practice of systematically integrating diagnostics with treatment, has evolved as a field of medicine. In the context of ultrasound based theranostics, both traditional microbubbles and inorganic nanoparticles have emerged as technologies of clinical interest. Ultrasound induced microbubble cavitation has demonstrated efficacy in a variety of applications, including thrombolysis, tumor ablation, targeted microvascular flow enhancement, and targeted drug and gene delivery. This commentary summarizes the mechanisms and applications of ultrasound-based theranostics in cardiovascular medicine, including its impact in pediatric cardiology. It also provides an overview of ongoing clinical trials for theranostics in cardiovascular medicine.

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Acknowledgement

The authors thank Dr. Fuad Zain, HeartStudio, Rochester, NY for the illustrative figure.

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Authors and Affiliations

  1. The Helen B. Taussig Heart Center, The Johns Hopkins Hospital, The Johns Hopkins University School of Medicine, M2315, 1800 Orleans St, Baltimore, MD, 21287, USA

    Vivek Jani & Shelby Kutty

  2. Division of Cardiology, Department of Pediatrics, Augusta University, Augusta, GA, USA

    Pushpa Shivaram

  3. Division of Cardiology, University of Nebraska Medical Center College of Medicine, Omaha, NE, USA

    Thomas R. Porter

Authors
  1. Vivek Jani
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  2. Pushpa Shivaram
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  3. Thomas R. Porter
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  4. Shelby Kutty
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Correspondence to Shelby Kutty.

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Jani, V., Shivaram, P., Porter, T.R. et al. Ultrasound Theranostics in Adult and Pediatric Cardiovascular Research. Cardiovasc Drugs Ther 35, 185–190 (2021). https://doi.org/10.1007/s10557-020-07016-7

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  • DOI: https://doi.org/10.1007/s10557-020-07016-7

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