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Central and Peripheral Irisin Differentially Regulate Blood Pressure

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Abstract

Introduction

Irisin is a newly identified 112 amino acid hormone, derived as a product of fibronectin type III domain containing 5 (FNDC5), which is highly related to metabolic activity in skeletal muscle and brown fat. The effects of irisin on cardiovascular functions are unknown.

Purpose

To explore the effects of central and peripheral irisin on cardiovascular functions.

Methods

Irisin was either administrated into 3rd ventricle of rats or intravenously, and its effects on blood pressure and cardiac contractibility measured.

Results

Administration of recombinant human irisin into the 3rd brain ventricle of rats activated neurons in the paraventricular nuclei of the hypothalamus. Central administration of irisin increased blood pressure and cardiac contractibility. Exogenous irisin reversed atenolol-induced inhibition of cardiac contractibility. In contrast, peripheral administration of irisin reduced blood pressure in both control and spontaneously hypertensive rats. Irisin dilated mesenteric artery rings through ATP-sensitive potassium channels.

Conclusion

Our studies indicate that central and peripheral irisin may differentially regulate cardiovascular activities.

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Acknowledgments

This work was supported by grants from the National Natural Science Foundation of China (81330010 and 81390354 to W.Z.), American Diabetes Association grant #1-13-BS-225 (to W.Z.), and the National Institute of Health grants 5R37DK043225 (to M. M.), HL105114 (to E. C.) and HL122664 (to L. C.).

Disclosures

None.

Author information

Authors and Affiliations

  1. Department of Surgery, University of Michigan, 4618B, MS II, 1301 E. Catherine Street, Ann Arbor, MI, 48109, USA

    Weizhen Zhang, Chao Zhang, Ziru Li, Biaoxin Chai, Jiyao Li & Michael Mulholland

  2. Diabetes Center, Shenzhen University Health Science Center, Shenzhen, 518060, China

    Weizhen Zhang

  3. Department of Internal Medicine, University of Michigan, 2800 Plymouth Rd, Ann Arbor, MI, 48109, USA

    Lin Chang, Ruthann Zhang & Eugene Chen

Authors
  1. Weizhen Zhang
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  2. Lin Chang
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  3. Chao Zhang
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  4. Ruthann Zhang
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  5. Ziru Li
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  6. Biaoxin Chai
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  7. Jiyao Li
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  8. Eugene Chen
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  9. Michael Mulholland
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Corresponding authors

Correspondence to Weizhen Zhang or Lin Chang.

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Zhang, W., Chang, L., Zhang, C. et al. Central and Peripheral Irisin Differentially Regulate Blood Pressure. Cardiovasc Drugs Ther 29, 121–127 (2015). https://doi.org/10.1007/s10557-015-6580-y

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  • DOI: https://doi.org/10.1007/s10557-015-6580-y

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