Abstract
Objective
To determine the effects of n3-PUFA supplementation, in the dose used in the GISSI-Prevenzione study, on indices of heart rate variability (HRV) in patients following myocardial infarction (AMI).
Materials and methods
Open label randomised single blind controlled trial. Thirty eight patients post AMI, stable on standard secondary prevention drug therapy were single blind randomised to receive either Omacor 1 g/day (n = 21) or usual care (n = 17). HRV indices (time and frequency-domain) were measured at baseline and following 3 months of treatment.
Results
At baseline there were no significant differences in clinical, biochemical or HRV indices between patient groups. After 3 months therapy there were no observed changes in measured HRV indices in either the Omacor supplemented or ‘usual care’ groups.
Conclusions
Three month supplementation of omega 3 PUFA (Omacor) 1 g/day has no effect on HRV is patients post AMI.
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Hamaad, A., Kaeng Lee, W., Lip, G.Y.H. et al. Oral Omega n3-PUFA Therapy (Omacor) Has No Impact on Indices of Heart Rate Variability in Stable Post Myocardial Infarction Patients. Cardiovasc Drugs Ther 20, 359–364 (2006). https://doi.org/10.1007/s10557-006-0295-z
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DOI: https://doi.org/10.1007/s10557-006-0295-z