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Milrinone Administered Before Ischemia or Just After Reperfusion, Attenuates Myocardial Stunning in Anesthetized Swine

  • Basic Pharmacology
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Abstract

Purpose

We assessed the dose or timing effect of milrinone administered against myocardial stunning in 37 anesthetized open-chest swine.

Methods

All swine were subjected to 12-min ischemia followed by reperfusion to produce myocardial stunning. Group A (n = 12) received saline in place of milrinone both before and after ischemia. Group B (n = 9) and C (n = 9) received intravenous milrinone at a rate of 5 μg/kg/min for 10 min followed by 0.5 μg/kg/min for 10 min and 10 μg/kg/min for 10 min followed by 1 μg/kg/min for 10 min, respectively, until 30 min before coronary occlusion. Group D (n = 7) received the same dose of milrinone as group B starting 1 min after reperfusion. Myocardial contractility was assessed by percentage segment shortening (%SS).

Results

Five swine in group A and two swine in groups B and C each had ventricular fibrillation or tachycardia after reperfusion, and were thus excluded from further analysis. The percentage changes of %SS from the baseline 90 min after reperfusion in groups B, C, and D were 78 ± 9%, 82 ± 13%, and 79 ± 7%, respectively, which were significantly higher than those in group A (43 ± 13%).

Conclusion

We conclude that milrinone administered before ischemia or just after reperfusion attenuates myocardial stunning.

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Authors and Affiliations

  1. Department of Anesthesiology, Nagasaki University School of Medicine, 1-7-1 Sakamoto, Nagasaki, 852-8501, Japan

    Tadasuke Use, Tetsuji Makita, Hiroyuki Ureshino, Sungsam Cho, Osamu Yoshitomi, Daiji Akiyama, Motoko Oshibuchi, Tetsuya Hara & Koji Sumikawa

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  1. Tadasuke Use
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  2. Tetsuji Makita
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  3. Hiroyuki Ureshino
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  4. Sungsam Cho
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Correspondence to Tetsuji Makita.

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Use, T., Makita, T., Ureshino, H. et al. Milrinone Administered Before Ischemia or Just After Reperfusion, Attenuates Myocardial Stunning in Anesthetized Swine. Cardiovasc Drugs Ther 20, 327–334 (2006). https://doi.org/10.1007/s10557-006-0166-7

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  • DOI: https://doi.org/10.1007/s10557-006-0166-7

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