References
Brunton TL. Use of Nitrate of Amyl in Angina Pectoris. Lancet 1987;2:628–629.
Goldstein RE, Rosing DR, Redwood DR, et al. Clinical and Circulatory effects of Isosorbide Dinitrate: Comparison with Nitroglycerin. Circulation 1971;43:629–640.
Thadani U, Parker JO. Influence of Glyceryl Trinitrate During Supine and Upright Exercise in Patients with Angina Pectoris. Br Heart J 1978;40:1229–1236.
Thadani U, Fung HL, Darke AC, Parker JO. Oral Isosorbide Dinitrate In Angina Pectoris: Comparison Of Duration Of Action And Dose-Response Relationship And Duration Of Action During Acute Therapy. Circulation 1980;62:491–502.
Thadani U, Manyari D, Parker JO, Fung HL. Tolerance To The Circulatory Effects Of Oral Isosorbide Dinitrate: Rate of Development And Cross Tolerance To Glyceryl Trinitrate. Circulation 1980b;61:526–535.
Thadani U, Fung HL, Karke AC, Parker JO. Oral Isosorbide Dinitrate In Angina Pectoris: Comparison Of Duration Of Action And Dose-Response Relation During Acute And Sustained Therapy. Am J Cardiol 1982;49:411–419.
Parker JO, Jung HL. Transdermal Nitroglycerin In Angina Pectoris. Am J Cardiol 1984;54:471–476.
Thadani U, Hamilton SF, Olson E, et al. Transdermal Nitroglycerin Patches In Angina Pectoris. Annals of Internal Medicine 1986;105:485–492.
Steering Committee, Transdermal Nitroglycerin Cooperative Study. Acute and Chronic Antianginal Efficacy of Continuous Twenty-Four Hour Application of Transdermal Nitroglycerin. Am J Cardiol 1991;68:1263–1273.
Parker JO, Farrell B, Lahey KA, Moe G. Effect of Intervals Between Doses On The Development Of Tolerance To Isosorbide Dinitrate. N Eng J Med 1987;316:1440–1444.
Thadani U, Hamilton SF, Olson E, et al. Duration Of Effects And Tolerance Of Slow Release Isosorbide-5-Mononitrate For Angina Pectoris. Am J Cardiol 1987a;59:756–762.
Thadani U, Prasad R, Hamilton SF, et al. Usefulness Of Twice Daily Isosorbide-5-Mononitrate In Preventing Development Of Tolerance In Angina Pectoris. Am J Cardiol 1987c;60:477–482.
Zimrin D, Reichek N, Bogin K, et al. Antianginal Effects Of Intavenous Nitroglycerin. Circulation 1988;77:1376–1384.
Cowan JC, Bourke JP, Reid DS. Prevention of Tolerance to Nitroglycerin Patches by Overnight Removal. Am J Cardiol 1987;60:271–275.
DeMots H, Glasser SP. Intermittent Transdermal Nitroglycerin Therapy In The Treatment Of Chronic Stable Angina. J Am Coll Cardiol 1989;13:786–795.
Thadani U, Lipicky RJ. Short And Long Acting Oral Nitrates For Stable Angina Pectoris. Cardiovasc Drugs Ther 1994;8:611–623.
Thadani U, Lipicky RJ. Ointments And Transdermal Nitroglycerin Patches For Stable Angina Pectoris. Cardiovasc Drugs Ther 1994;8:625–633.
Thadani U. Treatment Of Stable Angina. Curr Opin Cardiol 1999;14:349–358.
Thadani U. Nitrate Tolerance, Rebound And Their Clinical Relevance In Stable Angina Pectoris, Unstable Angina And Heart Failure. Cardiovasc Drugs Ther 1996;10:735–742.
Parker JO, Van Koughnott KA, Fung HL. Transdermal Isosorbide Dinitrate in Angina Pectoris. Am J Coll Cardiol 1984;54:8–13.
Kowaluk E, Hough K, Fung H-L. Effect of Intermittent Exposure and Drug-Free Intervals in the in-vitro vascular Tolerance to Nitroglycerin. Life Sci 1989;44:1157–1163.
Crandall LA, Leak CD, Loventhart AS, et al. Acquired tolerance to and cross tolerance between the nitric acid esters and sodium nitrite in man. J Pharmacol Experimental Ther 1931;41:103–119.
Ignarro LJ, Lippton H, Edwards JE, et al. Mechanism of vascular smooth muscle relaxation by organic nitrates, nitrites, nitroprusside and nitric oxide: Evidence for the involvement of S-nitrosothiole as active intermediates. J Pharmacol Experimental Ther 1981;218:739–748.
Needleman P, Johnson EM Jr. Mechanism of tolerance development to organic nitrates. Pharmacology and Experimental Therapeutics 1973;184:709–715.
Dupuis J, Lalonde G, Lemieux R, et al. Tolerance to Intravenous Nitroglycerin in Patients with Congestive Heart Failure: Role of Increased Intravascular Volume, Neurohumoral Activation and Lack of Prevention with N-acetylcysteine. J Am Coll Cardiol 1990;16:923–931.
Chen Z, Zhang J, Stamier JS. Identification of the enzymatic mechanism of nitroglycerin bioactivation. PNAS 2002;99(12):8306–1311.
Parker JD, Farrell B, Fenton T, et al. Counter-Regulatory Responses to Continuous and Intermittent Therapy with Nitroglycerin. Circulation 1991;84:2336–2345.
Sage PR, de la Lande IS, Stafford I, et al. Nitroglycerin Tolerance in Human Vessels: Evidence for Impaired Nitroglycerin Bioconversion. Circulation 2000;102:2810–2815.
Wang EQ, Lee WI, Brazeau D, et al. cDNA Microarray Analysis of Vascular Gene Expression After Nitric Oxide Donor Infusion s in Rats: Implications for Nitrate Tolerance Mechanisms. AAPS Pharm Sci 2002;4(2):1–11.
Frame MD, Fox RJ, Kim D, et al. Diminished Arteriolar Responses in nitrate tolerance involve ROS and angiotensin II. Am J Physiol Heart Circ Physiol 2202;282:H2377–H2385.
Munzel T, Giaid A, Kurz S, et al. Evidence For A Role Of Endothelin 1 And Kinase C In Nitroglycerin Tolerance. Proc Natl Acad Sci USA 1995;92:5244–5248.
Kurz S, Hink U, Nickenig G, et al. Evidence for a Causal Role of the Renin-Angiotensin System in Nitrate Tolerance. Circulation 1999:99(24);3181–3187.
Loscalzo J. Folate and Nitrate-Induced Endothelial Dysfunction: A Simple Treatment for a Complex Pathobiology. Circulation 2001;1004:1086–1088.
Munzel T, Mulsch A, Kleschyov A. Mechanisms Underlying Nitroglycerin-Induced Superoxide Production in Platelets: Some Insight, More Questions. Circulation 2002;106:170–172.
Munzel T, Sayegh H, Freeman B, et al. Evidence for Enhanced Vascular Superoxide Anion Production in Nitrate Tolerance: A Novel Mechanism Underlying Tolerance and Cross-Tolerance. J Clin Invest 1995;95:187–194.
Gori T, Parker JD. Nitrate tolerance: A Unifying Hypothesis. Circulation 2002;106:2510–2513.
Katz R, Levy WS, Buff L, et al. Prevention of Nitrate Tolerance with Angiotension Converting Enzyme Inhibitors. Circulation 1991;83:1271–1277.
Munzel T, Bassenge E. Long-term Angiotensin-Converting Enzyme Inhibition with High-Dose Enalapril Retards Nitrate Tolerance in Large Epicardial Arteries and Prevents Rebound Coronary Vasoconstriction in vivo. Circulation 93(11);1996:2052–2058.
Dakak N, Makhoul N, Flugelman MY, et al. Failure of Captopril to Prevent Nitrate Tolerance in Congestive Heart Failure Secondary to Coronary Artery Disease. Am J Cardiol 1990;66:608–613.
Parker JD, Parker JO. Effect of Therapy With an Angiotensin-Converting Enzyme Inhibitor on Hemodynamic and Counterregulatory Responses During Continuous Therapy with Nitroglycerin. J Am Coll Cardiol 1993;21:1445–1453.
Harai N, Kawano H, Yasue H, et al. Attenuation of Nitrate Tolerance and Oxidative Stress by an Angiotensin II Receptor Blocker in Patients with Coronary Spastic Angina. Circulation 2003;108:1446–1450.
Cotter G, Metzkor-Cotter E, Kaluski E, et al. Usefulness of Losartan, Captopril, and Furosemide in Preventing Nitrate Tolerance and Improving Control of Unstable Angina Pectoris. Am J Cardiol 1998;82:1024–1029.
Milone SD, Azevedo ER, Forster C, et al. The angiotensin II-Receptor Antagonist Losartan Does Not Prevent Hemodynamic or Vascular Tolerance to Nitroglycerin. J Cardiovasc Pharmacol 1999;34(5):645–650.
Longobardi G, Ferrara N, Leosco D, et al. Angiotensin II-Receptor Antagonist Losartan Does Not Preventg Nitroglycerin Tolerance in Patients with Coronary Artery Disease. Cardiovasc Drugs Ther 2004;18:363–370.
Gori T, Burstein JM, Ahmed S, et al. Folic Acid Prevents Nitroglycerin-Induced Nitric Oxide Synthase Dysfunction and Nitrate Tolerance: A Human In Vivo Study. Circulation 2001;104:1119–1123.
McVeigh GE, Hamilton P, Wilson M, et al. Platelet Nitric Oxide and Superoxide Release During the Development of Nitrate Tolerance: Effect of Supplemental Ascorbate. Curculation 2002;106:208–213.
Hideki W, Masaaki K, Sadanori O, et al. Randomized, Double-Blind, Placebo-Controlled Study of Supplemental Vitamin E on Attenuation of the Development of Nitrate Tolerance. Circulation 1997;96(8):2545–2550.
Parker JO, Parker JD, Caldwell RW, et al. The Effect of Supplemental L-Arginine on Tolerance Development During Continuous Transdermal Nitroglycerin Therapy. J Am Coll Cardiol 2002;2002:1199–1203.
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Thadani, U. Prevention of Nitrate Tolerance with Angiotensin II Receptor Type 1 Blocker in Patients with Stable Angina: Yet Another Failed Strategy to Prevent Tolerance. Cardiovasc Drugs Ther 18, 339–342 (2004). https://doi.org/10.1007/s10557-005-5056-x
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DOI: https://doi.org/10.1007/s10557-005-5056-x