Update on gastric cancer treatments and gene therapies

  • Alessio Biagioni
  • Ileana Skalamera
  • Sara Peri
  • Nicola SchiavoneEmail author
  • Fabio CianchiEmail author
  • Elisa Giommoni
  • Lucia Magnelli
  • Laura Papucci


Gastric cancer is an active topic of clinical and basic research due to high morbidity and mortality. To date, gastrectomy and chemotherapy are the only therapeutic options for gastric cancer patients, but drug resistance, either acquired or primary, is the main cause for treatment failure. Differences in development and response to cancer treatments have been observed among ethnically diverse GC patient populations. In spite of major incidence, GC Asian patients have a significantly better prognosis and response to treatments than Caucasian ones due to genetic discordances between the two populations. Gene therapy could be an alternative strategy to overcome such issues and especially CRISPR/Cas9 represents one of the most intriguing gene-editing system. Thus, in this review article, we want to provide an update on the currently used therapies for the treatment of advanced GC.

Graphical abstract


Gastric cancer Chemotherapy Metastases Gene therapy CRISPR 


Financial support

Dr. Alessio Biagioni was supported by a postdoctoral fellowship of the Italian Foundation for Cancer Research (AIRC).

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.


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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • Alessio Biagioni
    • 1
  • Ileana Skalamera
    • 2
  • Sara Peri
    • 1
    • 3
  • Nicola Schiavone
    • 1
    Email author
  • Fabio Cianchi
    • 2
    Email author
  • Elisa Giommoni
    • 4
  • Lucia Magnelli
    • 1
  • Laura Papucci
    • 1
  1. 1.Department of Experimental and Clinical Biomedical SciencesUniversity of FlorenceFlorenceItaly
  2. 2.Department of Experimental and Clinical MedicineUniversity of FlorenceFlorenceItaly
  3. 3.Department of Biotechnology, Chemistry and PharmacyUniversity of SienaSienaItaly
  4. 4.Medical Oncology Unit, Department of Oncology and Robotic SurgeryAOU CareggiFlorenceItaly

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