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Cross-talk between lung cancer and bones results in neutrophils that promote tumor progression

  • Patrick O. Azevedo
  • Ana E. Paiva
  • Gabryella S. P. Santos
  • Luiza Lousado
  • Julia P. Andreotti
  • Isadora F. G. Sena
  • Carlos A. Tagliati
  • Akiva Mintz
  • Alexander Birbrair
NON-THEMATIC REVIEW

Abstract

Lung cancer is the leading cause of cancer mortality around the world. The lack of detailed understanding of the cellular and molecular mechanisms participating in the lung tumor progression restrains the development of efficient treatments. Recently, by using state-of-the-art technologies, including in vivo sophisticated Cre/loxP technologies in combination with lung tumor models, it was revealed that osteoblasts activate neutrophils that promote tumor growth in the lung. Strikingly, genetic ablation of osteoblasts abolished lung tumor progression via interruption of SiglecFhigh–expressing neutrophils supply to the tumor microenvironment. Interestingly, SiglecFhigh neutrophil signature was associated with worse lung adenocarcinoma patients outcome. This study identifies novel cellular targets for lung cancer treatment. Here, we summarize and evaluate recent advances in our understanding of lung tumor microenvironment.

Keywords

Osteoblasts Neutrophils Lung Tumor microenvironment 

Notes

Funding information

Alexander Birbrair is supported by a grant from Instituto Serrapilheira/Serra-1708-15285, a grant from Pró-reitoria de Pesquisa/Universidade Federal de Minas Gerais (PRPq/UFMG) (Edital 05/2016), a grant from FAPEMIG [Rede Mineira de Engenharia de Tecidos e Terapia Celular (REMETTEC, RED-00570-16)], and a grant from FAPEMIG [Rede De Pesquisa Em Doenças Infecciosas Humanas E Animais Do Estado De Minas Gerais (RED-00313-16)]; Akiva Mintz is supported by the National Institute of Health (1R01CA179072-01A1) and by the American Cancer Society Mentored Research Scholar grant (124443-MRSG-13-121-01-CDD).

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflicts of interest.

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • Patrick O. Azevedo
    • 1
  • Ana E. Paiva
    • 1
  • Gabryella S. P. Santos
    • 1
  • Luiza Lousado
    • 1
  • Julia P. Andreotti
    • 1
  • Isadora F. G. Sena
    • 1
  • Carlos A. Tagliati
    • 2
  • Akiva Mintz
    • 3
  • Alexander Birbrair
    • 1
    • 3
  1. 1.Department of PathologyFederal University of Minas GeraisBelo HorizonteBrazil
  2. 2.Department of Clinical and Toxicological AnalysisFederal University of Minas GeraisBelo HorizonteBrazil
  3. 3.Department of RadiologyColumbia University Medical CenterNew YorkUSA

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