Cancer and Metastasis Reviews

, Volume 32, Issue 1–2, pp 77–82 | Cite as

Mouse models of lung squamous cell carcinomas

  • Michael S. You
  • Lucina C. Rouggly
  • Ming You
  • Yian Wang
Article

Abstract

Although many mouse models of lung adenocarcinoma exist, only a few mouse lung squamous cell carcinoma models have been developed. Since most clinical chemoprevention trials of lung cancer are performed in subjects with bronchial dysplasia, development of a lung squamous cell carcinoma mouse model sufficient for chemoprevention studies is a high priority. We have shown that lung squamous cell carcinomas can be induced chemically in several strains of mice (1), and that this chemically induced lung squamous cell carcinoma model is applicable to cancer chemoprevention studies. Recently, Ji et al. (2) have shown that simultaneous activation of KrasG12D and inactivation of Lkb1 results in a broader histological range of lung tumors, with approximately 50 % of the lung tumors being squamous cell carcinomas. Here, we review the application of mouse lung squamous cell carcinoma models with different stages of squamous lesions and squamous cell carcinomas to cancer development and chemoprevention studies.

Keywords

Mouse models Lung squamous cell carcinoma Chemical-induced Transgenic Chemoprevention 

References

  1. 1.
    Wang, Y., Zhang, Z., Yan, Y., Lemon, W. J., LaRegina, M., Morrison, C., et al. (2004). A chemically induced model for squamous cell carcinoma of the lung in mice: histopathology and strain susceptibility. Cancer Research, 64, 1647–1654.Google Scholar
  2. 2.
    Ji, H., Ramsey, M. R., Hayes, D. N., Fan, C., McNamara, K., Kozlowski, P., et al. (2007). LKB1 modulates lung cancer differentiation and metastasis. Nature, 448, 807–810.PubMedCrossRefGoogle Scholar
  3. 3.
    Jemal, A., Siegel, R., Xu, J., & Ward, E. (2010). Cancer Statistics, 2010. CA: A Cancer Journal for Clinicians, 60, 277–300.CrossRefGoogle Scholar
  4. 4.
    Doll, R., & Hill, A. (1954). The mortality of doctors in relation to their smoking habits; a preliminary report. British Medical Journal, 1, 1451–1455.PubMedCrossRefGoogle Scholar
  5. 5.
    Herzog, C. R., Lubet, R. A., & You, M. (1997). Genetic alterations in mouse lung tumors: implications for cancer chemoprevention. Journal of Cellular Biochemistry. Supplement, 28–29, 49–63.PubMedCrossRefGoogle Scholar
  6. 6.
    Witschi, H. P., Espiritu, I., Maronpot, R. R., Pinkerton, K. E., & Jones, A. D. (1997). The carcinogenic potential of the gas phase of environmental tobacco smoke. Carcinogenesis, 18, 2035–2042.PubMedCrossRefGoogle Scholar
  7. 7.
    Witschi, H., Espiritu, I., Peake, J. L., Wu, K., Maronpot, R. R., & Pinkerton, K. E. (1997). The carcinogenicity of environmental tobacco smoke. Carcinogenesis, 18, 575–586.PubMedCrossRefGoogle Scholar
  8. 8.
    Shopland, D. R., Fyre, J., II, & Pechacek, T. F. (1991). Smoking attributable cancer mortality in 1991: is lung cancer now the leading cause of death among smokers in the United States. Journal of the National Cancer Institute, 83, 1142–1147.PubMedCrossRefGoogle Scholar
  9. 9.
    Doll, R., & Hill, A. (1952). A study of the aetiology of carcinoma of the lung. British Medical Journal, ii, 1271–1286.CrossRefGoogle Scholar
  10. 10.
    Minna, J. D. (1993). The molecular biology of lung cancer pathogenesis. Chest, 103, 449–456.CrossRefGoogle Scholar
  11. 11.
    Jemal, A., Siegel, R., Ward, E., Murray, T., Xu, J., Smigal, C., et al. (2006). Cancer statistics, 2006. CA: A Cancer Journal for Clinicians, 56, 106–130.CrossRefGoogle Scholar
  12. 12.
    Hong, W. K., & Sporn, M. B. (1997). Recent advances in chemoprevention of cancer. Science, 278, 1073–1077.PubMedCrossRefGoogle Scholar
  13. 13.
    Travis, W. D., Travis, L. B., & Devesa, S. S. (1995). Lung cancer. Cancer, 75, 191–202.PubMedCrossRefGoogle Scholar
  14. 14.
    Malkinson, A. M. (1992). Primary lung tumors in mice: an experimentally manipulable model of human adenocarcinoma. Cancer Research, 52, 2670s–2676s.PubMedGoogle Scholar
  15. 15.
    Auerbach, O., Forman, J. B., Gere, J. B., Kassouny, D. Y., Muehsam, G. E., Petrick, T. G., et al. (1957). Changes in the bronchial epithelium in relation to smoking and cancer of the lung; a report of progress. The New England Journal of Medicine, 256, 97–104.PubMedCrossRefGoogle Scholar
  16. 16.
    Auerbach, O., Stout, A. P., Hammond, E. C., & Garfinkel, L. (1961). Changes in bronchial epithelium in relation to cigarette smoking and in relation to lung cancer. The New England Journal of Medicine, 265, 253–267.PubMedCrossRefGoogle Scholar
  17. 17.
    Saccomanno, G., Archer, V. E., Auerbach, O., Saunders, R. P., & Brennan, L. M. (1974). Development of carcinoma of the lung as reflected in exfoliated cells. Cancer (Philadelphia), 33, 256–270.CrossRefGoogle Scholar
  18. 18.
    Becci, P. J., McDowell, E. M., & Trump, B. F. (1978). The respiratory epithelium. VI. Histogenesis of lung tumors induced by benzo[a]pyrene-ferric oxide in the hamster. Journal of the National Cancer Institute (Bethesda), 61, 607–618.Google Scholar
  19. 19.
    No authors (1986). Tobacco smoking. IARC Monogr. Eval. Carcinog. Risk of Chemical Human 38, 35–394.Google Scholar
  20. 20.
    Hammar, S. P., Bolen, J. W., Bockus, D., Remington, F., & Friedman, S. (1985). Ultrastructural and immunohistochemical features of common lung tumors: an overview. Ultrastructural Pathology, 9, 283–318.PubMedCrossRefGoogle Scholar
  21. 21.
    Chao, A., Thun, M. J., Jacobs, E. J., Henley, S. J., Rodriguez, C., & Calle, E. E. (2000). Cigarette smoking and colorectal cancer mortality in the cancer prevention study II. Journal of the National Cancer Institute (Bethesda), 92, 1888–1896.CrossRefGoogle Scholar
  22. 22.
    Yoshimoto, T., Hirao, F., Sakatani, M., Nishikawa, H., & Ogura, T. (1977). Induction of squamous cell carcinoma in the lung of C57BL/6 mice by intratracheal instillation of benzo[a]pyrene with charcoal powder. Gann, 68, 343–352.PubMedGoogle Scholar
  23. 23.
    Yoshimoto, T., Inoue, T., Iizuka, H., Nishikawa, H., Sakatani, M., Ogura, T., et al. (1980). Differential induction of squamous cell carcinomas and adenocarcinomas in mouse lung by intratracheal instillation of benzo(a)pyrene and charcoal powder. Cancer Research, 40, 4301–4307.PubMedGoogle Scholar
  24. 24.
    Henry, C. J., Billups, L. H., Avery, M. D., Rude, T. H., Dansie, D. R., Lopez, A., et al. (1981). Lung cancer model system using 3-methylcholanthrene in inbred strains of mice. Cancer Research, 41, 5027–5032.PubMedGoogle Scholar
  25. 25.
    Lijinsky, W., & Reuber, M. D. (1988). Neoplasms of the skin and other organs observed in Swiss mice treated with nitrosoalkylureas. Journal of Cancer Research and Clinical Oncology, 114, 245–249.PubMedCrossRefGoogle Scholar
  26. 26.
    You, M., & Bergman, G. (1998). Preclinical and clinical models of lung cancer chemoprevention. Hematology/Oncology Clinics of North America, 12, 1037–1053.PubMedCrossRefGoogle Scholar
  27. 27.
    Wang, Y., Zhang, Z., Garbow, J. R., Rowland, D. J., Lubet, R. A., Sit, D., et al. (2009). Chemoprevention of lung squamous cell carcinoma in mice by a mixture of Chinese herbs. Cancer Prevention Research (Philadelphia, PA), 2, 634–640.CrossRefGoogle Scholar
  28. 28.
    Wang, Y., James, M., Wen, W., Lu, Y., Szabo, E., Lubet, R. A., et al. (2010). Chemopreventive effects of pioglitazone on chemically induced lung carcinogenesis in mice. Molecular Cancer Therapeutics, 9, 3074–3082.PubMedCrossRefGoogle Scholar
  29. 29.
    Hudish, T. M., Opincariu, L. I., Mozer, A. B., Johnson, M. S., Cleaver, T. G., Malkoski, S. P., et al. (2012). N-nitroso-trischloroethylurea induces premalignant squamous dysplasia in mice. Cancer Prevention Research (Philadelphia, Pa.), 5, 283–289.CrossRefGoogle Scholar
  30. 30.
    Launonen, V. (2005). Mutations in the human LKB1/STK11 gene. Human Mutation, 26, 291–297. Review.PubMedCrossRefGoogle Scholar
  31. 31.
    Farago, A. F., Snyder, E. L., & Jacks, T. (2012). SnapShot: lung cancer models. Cell, 149, 246–246.e1.Google Scholar
  32. 32.
    Rehm, S., Lijinsky, W., Singh, G., & Katyal, S. L. (1991). Mouse bronchiolar cell carcinogenesis. Histologic characterization and expression of Clara cell antigen in lesions induced by N-nitrosobis-(2-chloroethyl) ureas. The American Journal of Pathology, 139, 413–422.PubMedGoogle Scholar
  33. 33.
    Khan, N., Afaq, F., Kweon, M. H., Kim, K., & Mukhtar, H. (2007). Oral consumption of pomegranate fruit extract inhibits growth and progression of primary lung tumors in mice. Cancer Research, 67, 3475–3482.PubMedCrossRefGoogle Scholar
  34. 34.
    Ambrosini, V., Nanni, C., Pettinato, C., Fini, M., D’Errico, A., Trepidi, S., et al. (2007). Assessment of a chemically induced model of lung squamous cell carcinoma in mice by 18F-FDG small-animal PET. Nuclear Medicine Communications, 28, 647–652.Google Scholar

Copyright information

© Springer Science+Business Media New York 2012

Authors and Affiliations

  • Michael S. You
    • 1
  • Lucina C. Rouggly
    • 1
  • Ming You
    • 2
  • Yian Wang
    • 1
    • 3
  1. 1.Department of Surgery and The Alvin J Siteman Cancer CenterWashington University School of MedicineSt LouisUSA
  2. 2.Department of Pharmacology and ToxicologyMedical College of WisconsinMilwaukeeUSA
  3. 3.Department of Surgery and The Alvin J. Siteman Cancer CenterWashington UniversitySt. LouisUSA

Personalised recommendations