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Basic aspects of tumor cell fatty acid-regulated signaling and transcription factors

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Abstract

This article reviews the current knowledge and experimental research about the mechanisms by which fatty acids and their derivatives control specific gene expression involved during carcinogenesis. Changes in dietary fatty acids, specifically the polyunsaturated fatty acids of the ω-3 and ω-6 families and some derived eicosanoids from lipoxygenases, cyclooxygenases, and cytochrome P-450, seem to control the activity of transcription factor families involved in cancer cell proliferation or cell death. Their regulation may be carried out either through direct binding to DNA as peroxisome proliferator-activated receptors or via modulation in an indirect manner of signaling pathway molecules (e.g., protein kinase C) and other transcription factors (nuclear factor kappa B and sterol regulatory element binding protein). Knowledge of the mechanisms by which fatty acids control specific gene expression may identify important risk factors for cancer and provide insight into the development of new therapeutic strategies for a better management of whole body lipid metabolism.

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Acknowledgments

We are indebted to Dr. Kimberly K. McGhee (PhD) for technical English revision. This work was supported by grants from Consejo Nacional de Investigaciones Cientìficas y Técnicas (CONICET-Argentina), Ministerio de Ciencias y tecnología de Córdoba (MINCYT-CBA) y Secretaria de Ciencia Y Tecnología de la Universidad Nacional de Còrdoba (SECYT-UNC). Also by the Mayo Clinic Pancreatic SPORE P50 CA102701, and Mayo Clinic Center for Cell Signaling in Gastroenterology P30 DK84567 to M.E.F.-Z.

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  1. Cátedra de Biología Celular, Histología y Embriología; Instituto de Biología Celular, Facultad de Ciencias Médicas CONICET-Argentina, Universidad Nacional de Córdoba, Av. Enrique Barros/Enfermera Gordillo S/N, Ciudad Universitaria, Córdoba, 5000, Argentina

    Andrea Comba, Aldo Renato Eynard, Mirta Ana Valentich & Marìa Eugenia Pasqualini

  2. Schulze Center for Novel Therapeutics, Gonda 19, 200 First Street SW, Rochester, MN, 55905, USA

    Yi-Hui Lin & Martín Ernesto Fernandez-Zapico

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  1. Andrea Comba
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Correspondence to Marìa Eugenia Pasqualini.

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Comba, A., Lin, YH., Eynard, A.R. et al. Basic aspects of tumor cell fatty acid-regulated signaling and transcription factors. Cancer Metastasis Rev 30, 325–342 (2011). https://doi.org/10.1007/s10555-011-9308-x

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