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CXCL12 / CXCR4 / CXCR7 chemokine axis and cancer progression

Cancer and Metastasis Reviews Aims and scope Submit manuscript

An Erratum to this article was published on 12 November 2010

Abstract

Chemokines, small pro-inflammatory chemoattractant cytokines that bind to specific G-protein-coupled seven-span transmembrane receptors, are major regulators of cell trafficking and adhesion. The chemokine CXCL12 (also called stromal-derived factor-1) is an important α-chemokine that binds primarily to its cognate receptor CXCR4 and thus regulates the trafficking of normal and malignant cells. For many years, it was believed that CXCR4 was the only receptor for CXCL12. Yet, recent work has demonstrated that CXCL12 also binds to another seven-transmembrane span receptor called CXCR7. Our group and others have established critical roles for CXCR4 and CXCR7 on mediating tumor metastasis in several types of cancers, in addition to their contributions as biomarkers of tumor behavior as well as potential therapeutic targets. Here, we review the current concepts regarding the role of CXCL12 / CXCR4 / CXCR7 axis activation, which regulates the pattern of tumor growth and metastatic spread to organs expressing high levels of CXCL12 to develop secondary tumors. We also summarize recent therapeutic approaches to target these receptors and/or their ligands.

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Acknowledgements

We apologize to the many authors whose excellent work we could not cite owing to space limitation. Research in the authors’ laboratory is supported by the National Natural funding of China (30973012,81071747), National key program (973) for Basic Research of China (NO2010CB504300), Shanghai Education Committee Key Discipline and Specialties Foundation Project Number J50208, and Shanghai Pujiang Program (10PJ1406400). Taichman and Pienta are supported by the National Cancer Institute (CA93900).

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An erratum to this article can be found at http://dx.doi.org/10.1007/s10555-010-9266-8

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Sun, X., Cheng, G., Hao, M. et al. CXCL12 / CXCR4 / CXCR7 chemokine axis and cancer progression. Cancer Metastasis Rev 29, 709–722 (2010). https://doi.org/10.1007/s10555-010-9256-x

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