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Clinical biomarkers of kinase activity: examples from EGFR inhibition trials

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Abstract

Introduction

Tumor response and duration of patient survival after treatment with inhibitors of the epidermal growth factor receptor (EGFR) varies considerably between different kinds of EGFR inhibitors, different combination schedules, but also between individual patients.

Discussion

Development and introduction of biomarkers into clinical practice is necessary to predict treatment response and thereby to individualize cancer therapy. Due to specific interactions of EGFR inhibitors with biological effects of irradiation, biomarkers are expected to differ for radiation oncology compared to application of the drugs alone or within chemotherapy treatment schedules and therefore need to be established and tested separately.

Objectives

The review summarizes the current status of potential predictors for the effect of EGFR inhibitors used as single agents or in combination with chemotherapy.

Conclusion

Based on this knowledge and on preclinical radiotherapy data, candidate biomarkers and further research strategies for radiation oncology are discussed.

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Acknowledgements

The authors are supported by a grant of the German Research Council (BA 1433/6-1) within the research network “Mechanisms of the heterogeneity of the efficacy of EGFR inhibitors for radiotherapy of solid tumours” (DFG-PAK 190).

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Krause, M., Baumann, M. Clinical biomarkers of kinase activity: examples from EGFR inhibition trials. Cancer Metastasis Rev 27, 387–402 (2008). https://doi.org/10.1007/s10555-008-9141-z

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