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TNF-α in promotion and progression of cancer

Abstract

Tumour necrosis factor alpha is a member of the TNF/TNFR cytokine superfamily. In common with other family members, TNF-α is involved in maintenance and homeostasis of the immune system, inflammation and host defence. However, there is a ‘dark side’ to this powerful cytokine; it is now clear that, especially in middle and old age, TNF-α is involved in pathological processes such as chronic inflammation, autoimmunity and, in apparent contradiction to its name, malignant disease. This article will discuss the involvement of TNF-α in the inflammatory network that contributes to all stages of the malignant process, and consider the possibility that TNF-α may be a target for cancer therapy.

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Balkwill, F. TNF-α in promotion and progression of cancer. Cancer Metastasis Rev 25, 409–416 (2006). https://doi.org/10.1007/s10555-006-9005-3

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Keywords

  • TNF-α
  • Inflammation
  • Cytokine
  • Chemokine