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Should aortic stiffness parameters be used in MIS-C patient follow-up?

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Abstract

We evaluated the short- and long-term effects of multisystem inflammatory syndrome in children (MIS-C) on their cardiovascular system. The study population consisted of 38 MIS-C patients and 55 control patients. Standard echocardiographic measurements and aortic stiffness parameters were compared between the two groups at different time points. During the standard echocardiographic examination at the time of diagnosis, mitral valve insufficiency was detected in 42% of the cases, left ventricular systolic dysfunction in 36%, aortic valve insufficiency in 3%, tricuspid valve insufficiency in 13%, and coronary artery dilatation in 31%. The ejection fraction, pulse pressure of the experimental group were significantly lower than the control group (p < 0.01, p = 0.045, respectively). When aortic stiffness parameters were compared, it was seen that the parameters increased in the experimental group and the difference was significant for aortic distensibility. (p = 0.105, p = 0.029 respectively). When comparing the experimental group’s results at diagnosis and at the sixth month, there was a decrease in aortic stiffness parameters at the sixth month compared to the time of diagnosis, but the difference wasn’t significant (p = 0.514, p = 0.334). However, no statistically significant difference was detected when comparing the aortic distensibility results of the experimental group with the control group at the sixth month (p = 0.667). Our results showed that many pathological echocardiographic findings detected at diagnosis in MIS-C patients returned to normal within six months. Therefore, we believe that the cardiovascular follow-up period of MIS-C cases should be at least six months.

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Funding

The authors declared that this study has received no financial support.

Author information

Authors and Affiliations

  1. Department of Pediatric Infectious Disease, Gaziantep University School of Medicine, University Boulevard, Sehitkamil-Gaziantep, 27310, Turkey

    Hatice Uygun

  2. Department of Pediatric Cardiology, Adana City Hospital, Adana, Turkey

    Celal Varan

  3. Department of Pediatric Intensive Care, Gaziantep University School of Medicine, Gaziantep, Turkey

    Capan Konca

  4. Department of Pediatric Infectious Disease, Sanlıurfa Training and Research Hospital, Sanlıurfa, Turkey

    Nurettin Erdem

  5. Department of Biostatistics, Gaziantep University School of Medicine, Gaziantep, Turkey

    Tanyeli Guneyligil Kazaz

  6. Department of Pediatric Infectious Disease, School of Medicine, Adiyaman University, Adiyaman, Turkey

    Mehmet Turgut

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  1. Hatice Uygun
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Contributions

All authors contributed to the study conception and design. Material preparation, data collection and analysis were performed by [HU], [CV], [CK], [NE], [TGK] and [MT]. The first draft of the manuscript was written by [HU] and all authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.

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Correspondence to Hatice Uygun.

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Ethical approval

Ethics approval for the conduct of the study was obtained from the Institutional Review Board (approval no: 2022/1-14).

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It is not necessary as it is a retrospective study.

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The authors declare no competing interests.

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Uygun, H., Varan, C., Konca, C. et al. Should aortic stiffness parameters be used in MIS-C patient follow-up?. Int J Cardiovasc Imaging (2024). https://doi.org/10.1007/s10554-024-03133-8

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