Abstract
Aims
Previous studies demonstrated that remodeling after successful percutaneous coronary intervention (PCI) depends on the inflammatory response triggered by myocardial infarction (MI). The systemic immune-inflammation index (SII) is a novel inflammation index strongly associated with coronary artery disease. In our study, we sought to determine whether SII could predict Post-MI LV remodeling.
Methods and results
The study population included 528 patients (mean age 62.5 ± 10.2, 73% male) diagnosed with STEMI. Based on the increase in LVEDV within the first 12 months after STEMI, patients were divided into two groups. We categorized the ≥ 20% increase in LVEDV among remodelers (257 patients, 49%), and the other 271 patients (51%), as non-remodelers. To determine the relationship between laboratory parameters and LV remodeling, univariate and multivariate logistic regression models were used. In a univariate model, higher hs-CRP and SII values were associated with increased LVEDV. In a multivariate analysis, SII independently correlated with LV remodeling A cut-off value of 613.3 or higher for SII was significantly correlated with LV remodeling based on ROC analysis.
Conclusion
SII provides an easy-to-calculate and affordable biomarker for cardiovascular diseases. It may be used as a new biomarker to predict LV remodeling in patients with STEMI.
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Abbreviations
- CAD:
-
Coronary artery disease
- LV:
-
Left ventricle
- ACS:
-
Acute coronary syndrome
- DM:
-
Diabetes mellitus
- HT:
-
Hypertension
- PCI:
-
Percutaneous coronary intervention
- ROC:
-
Receiver operating characteristic curve
- ANOVA:
-
Analysis of variance
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All authors contributed to substantial contributions to conceptionand design of the data TST and HAK wrote the manucript and TST and HAK reviewed the manuscript.
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Kurklu, H.A., Tan, T.S. Systemic immune- inflammation index predicts post-MI left ventricular remodeling. Int J Cardiovasc Imaging 40, 991–1000 (2024). https://doi.org/10.1007/s10554-024-03064-4
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DOI: https://doi.org/10.1007/s10554-024-03064-4