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Volume and function changes of left atrium and left ventricle in patients with ejection fraction preserved heart failure measured by a three dimensional dynamic heart model

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Abstract

The accurate diagnosis of HFpEF is still challenging and controversial. In this study, we used 3D-DHM technology to compare the differences of cardiac structure and function between HFpEF patients and healthy controls, as well as the differences of two-dimensional and three-dimensional cardiac function in HFpEF patients. Echocardiography with 3D-DHM and conventional two-dimensional (2D) methods were applied to measure the volume and function parameters of left atrium and ventricle of patients with HFpEF and healthy controls. Significant differences of 3D cardiac function indexes including LVESV, 3D-LVEF, ESL, SV, CI, EDmass, LAVmax, LAVmin, LAEF, and LAVI were observed between patients with HFpEF and controls (P < 0.05). However, no significant difference of LVEDV and EDL were observed (P > 0.05). In addition, we found no significant between-group difference in 2D cardiac function indexes such as LVDD and 2D-LVEF (P > 0.05), but the LAD, LVSD, LVPW, IVS, E, E/A, and E/e ' were significantly different between groups (P < 0.05). There was no significant difference between 3D-LVEF and 2D-LVEF in the control group (P > 0.05), while 3D-LVEF in the HFpEF group was lower than 2D-LVEF(P < 0.05). Among the two-dimensional and three-dimensional parameters of HFpEF patients, the parameters related to diastolic function changed more significantly than those of the normal group, and the three-dimensional LVEF of HFpEF patients decreased. The three-dimensional cardiac function parameters analyzed by DHM can provide more information regarding myocardial mechanics.

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Data Availability

The datasets generated and analyzed during the current study are not publicly available but are available from the corresponding author on reasonable request.

Abbreviations

LV:

left ventricular

LVEDV:

left ventricular end diastolic volume

LVESV:

left ventricular end systolic volume

3D-LVEF:

three-dimensional left ventricular ejection fraction

EDL:

left ventricular end diastolic length

ESL:

left ventricular end systolic length

SV:

stroke volume

CI:

cardiac index

ED mass:

end diastolic mass

LAVmax:

Left atrial maximum volume

LAVmin:

left atrial minimum volume

LAEF:

left atrial ejection fraction

LAVI:

left atrial maximum volume index

LAD:

left atrial diameter

LVDD:

left ventricular end diastolic diameter

LVSD:

left ventricular end systolic diameter

2D-LVEF:

left ventricular two-dimensional ejection fraction

LVPW:

left ventricular posterior wall

IVS:

inter-ventricular septum

E:

mitral valve early diastolic peak velocity

E/A:

ratio of early diastolic to late diastolic peak velocity

E/e ':

the ratio of mitral orifice early diastolic and peak blood flow to Tissue Doppler mitral annulus early diastolic peak velocity

LVEDV simpson:

Simpson biplane method was used to calculate left ventricular end diastolic volume

LVESV simpson:

left ventricular end systolic volume

LVEF simpson:

left ventricular ejection fraction

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Acknowledgements

None.

Funding

This study was supported by the Scientific Research Project of Hunan Health Commission (202209023265).

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Authors and Affiliations

  1. Department of Ultrasonography, The People’s Hospital of Hunan Province (The First Affiliated Hospital of Hunan Normal University), No. 61 Jiefang West Road, Changsha, 410005, China

    Yi Zhang, Shen-Yi Li, Tian-Tian Lu, Rong Liu, Ming-Juan Chen & Qing-Qing Long

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  1. Yi Zhang
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  2. Shen-Yi Li
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  4. Rong Liu
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Contributions

YZ and SYL conceived and designed the study; RL, MJC and TTL collected data and conducted the study; SYL and QQL analyzed and interpreted the data; RL, MJC and YZ drafted the paper, YZ revised the paper; YZ had primary responsibility for final content. All authors read and approved the final manuscript.

Corresponding author

Correspondence to Shen-Yi Li.

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Ethics approval and consent to participate

This study was approved by the Ethics Committee of People’s Hospital of Hunan Province. All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and national research committee and with the 1964 Declaration of Helsinki and its later amendments or comparable ethical standards.

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The authors declare no competing interests.

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All participants provided written informed consent.

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Zhang, Y., Li, SY., Lu, TT. et al. Volume and function changes of left atrium and left ventricle in patients with ejection fraction preserved heart failure measured by a three dimensional dynamic heart model. Int J Cardiovasc Imaging 40, 509–516 (2024). https://doi.org/10.1007/s10554-023-03018-2

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  • DOI: https://doi.org/10.1007/s10554-023-03018-2

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