Abstract
Although cine MRI-derived radiomics features in the cardiac blood pool have been used to represent cardiac function and motion, the clinical relevance of radiomics features in the great vessels is still unknown. The aim of the present study was to test the hypothesis that cine MRI-derived radiomics features of the pulmonary artery (PA) can represent hemodynamic abnormalities in pulmonary hypertension (PH). With the approval of the institutional review board (IRB), 50 PH patients (21 males, 36–89 years old, diagnosed with right heart catheterization [RHC]) and 23 healthy volunteers (14 males, 26–80 years old) were retrospectively enrolled in this study. All participants underwent cardiac 4D flow and cine MRI (25 retrospective phases) at the right ventricular (RV) outflow tract (RVOT). A total of 93 radiomics features were extracted from RVOT cine images through a fixed size region of interest (ROI) at the proximal part of the PA. The peak values of the 6 first order features were different between the PH patients and controls. 4D flow-derived mean velocity in PA was related to ‘Kurtosis’ (r = 0.452,), ‘Range’ (r = 0.426), ‘Autocorrelation’ (r = 0.407), ‘Joint Average’ (r = 0.459), ‘Sum Average’ (r = 0.459), ‘High Gray Level Emphasis’ (r = 0.41), ‘Large Dependence High Gray Level Emphasis’ (r = 0.44), ‘High Gray Level Run Emphasis’ (r = 0.422), ‘Gray Level Variance’ (r = 0.419), ‘High Gray Level Zone Emphasis’ (r = 0.451), and ‘Small Area High Gray Level Emphasis’ (r = 0.415). Mean RV pressure was related to ‘Inverse Variance’ (r = 0.43) and ‘Run Percentage’ (r = 0.403). All p values < 0.05. Cine MRI-derived PA radiomics features have the potential to serve as novel imaging biomarkers for representing hemodynamic changes in pulmonary circulation.
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Funding
This study was supported by grants from the National Institutes of Health (K01HL121162, R03HL144891). This study was also supported by Bayer Pharmaceutical. The grant was paid to the institution not to individual investigators.
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All authors contributed to the study conception and design. Material preparation, data collection and analysis were performed by KL and RS. The first draft of the manuscript was written by KL and all authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.
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James C. Carr has disclosure: Siemens: research grant to institution; advisory board. Bayer: research grant to institution; advisory board; speaker. Bracco: advisory board. Guerbet: research grant to institution. Other authors have nothing to disclose.
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This study was performed in line with the principles of the Declaration of Helsinki. Approval was granted by the IRB of Northwestern University.
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Lin, K., Sarnari, R., Gordon, D.Z. et al. Cine MRI-derived radiomics features indicate hemodynamic changes in the pulmonary artery. Int J Cardiovasc Imaging 40, 287–294 (2024). https://doi.org/10.1007/s10554-023-03007-5
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DOI: https://doi.org/10.1007/s10554-023-03007-5