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The role of left ventricular hypertrophy measured by echocardiography in screening patients with ischaemia with non-obstructive coronary arteries: a cross-sectional study

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Abstract

Many patients with ischaemia with non-obstructive coronary arteries (INOCA) have a poor prognosis. This study aims to explore the diagnostic value of left ventricular hypertrophy (LVH)-related ultrasound parameters in INOCA patients. The study group consisted of 258 patients with INOCA in this retrospective cross-sectional study, and these patients were free of obstructive coronary artery disease, previous revascularization, atrial fibrillation, ejection fraction < 50%, major distortions of left ventricular geometry, suspected non-ischaemic causes. Control individuals were matched 1:1 with study group according to age, sex, cardiovascular risk factors, and time of hospital stay. According to left ventricular mass index (LVMI) and relative wall thickness, left ventricular geometry was composed of concentric hypertrophy, eccentric hypertrophy, concentric remodeling and normal geometry. LVH-related parameters, left ventricular geometry, demographic characteristics, laboratory parameters and other echocardiographic indicators were compared between the two groups. Subgroup analysis was performed based on sex. LVMI in the study group was higher than that in the control group (86.86 ± 18.83 g/m2 vs 82.25 ± 14.29 g/m2, P = 0.008). The ratio of LVH was higher in the study group (20.16% vs 10.85%, P = 0.006). After subgroup analysis based on sex, LVMI differences (85.77 ± 18.30 g/m2 vs 81.59 ± 14.64 g/m2, P = 0.014) and the ratio of LVH differences (25.00% vs 14.77%, P = 0.027) still existed in females between the two groups. There was no difference in the constituent ratio of left ventricular geometry between the two groups (P = 0.157). Sex-based subgroup analysis showed no difference in the constituent ratio of left ventricular geometry between the two groups in females (P = 0.242). The degree of LVH in the study group was higher than that in the control group, suggesting that LVH may play an important role in the occurrence and development of INOCA. Moreover, LVH-related ultrasound parameters may be of higher diagnostic value for female INOCA patients than for male INOCA patients.

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Data availability

The data presented in this study are available on request from the corresponding author.

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Acknowledgements

We would like to thank American Journal Experts for providing English editing service.

Funding

The authors sincerely grateful for the financial supports from the National Natural Science Foundation of China (Grant No. 82171946, 81873901), Basic Research and Frontier Exploration Key Project of Chongqing Science and Technology Commission (Grant No. cstc2019jcyj-zdxmX0020), CQMU Program for Youth Innovation in Future Medicine (Grant No. W0026), Kuanren Talents Program of the Second Affiliated Hospital of Chongqing Medical University (Grant No. KR2019G001), and Chongqing Science and Health Joint Medical Research Project-Young and Middle-aged High-level Talent Project (Grant No. 2020GDRC011).

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Authors and Affiliations

  1. Department of Ultrasound, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400010, People’s Republic of China

    Hao Yang, Hua Teng, Peng Luo, Ruqian Fu, Xiaoting Wang, Guang Qin, Min Gao & Jianli Ren

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  1. Hao Yang
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  2. Hua Teng
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  3. Peng Luo
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  5. Xiaoting Wang
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  6. Guang Qin
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  7. Min Gao
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  8. Jianli Ren
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Contributions

Conceptualization: HY and JR; investigation: HY, MG, RF, and GQ; formal analysis: HY and XW; manuscript preparation: HY, PL and HT; validation: HY and JR; funding acquisition: JR. All authors have read and agreed to the published version of the manuscript.

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Correspondence to Jianli Ren.

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Yang, H., Teng, H., Luo, P. et al. The role of left ventricular hypertrophy measured by echocardiography in screening patients with ischaemia with non-obstructive coronary arteries: a cross-sectional study. Int J Cardiovasc Imaging 39, 1657–1666 (2023). https://doi.org/10.1007/s10554-023-02879-x

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