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Native T1 and T2 reference values for maltese healthy cohort

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Abstract

Cardiac Magnetic Resonance (CMR) is increasingly being used for diagnosing various cardiac conditions. Parametric mapping enables quantitative myocardial characterization by directly measuring myocardial T1 and T2 values. However, reference values of parametric mapping are not standardized across different vendors and scanners, causing drawbacks for clinical implementation of this technique across different sites. We assessed the reference ranges of native T1 and T2 values in a healthy Maltese cohort to establish a local parametric mapping service. Healthy subjects [n = 51; mean age 36.0 (range 19–59) years] with normal cardiac function on CMR were recruited. Subjects underwent uniform parametric mapping pulse sequences [MOLLI 5b(3b)3b for native T1 mapping, and gradient echo single shot FLASH readout for T2 mapping] on a 3 T Siemens MAGNETOM Vida scanner. Native T1 and T2 values were measured by placing a region of interest within the interventricular septum at midventricular level. Intra- and inter-observer variability were assessed using Bland–Altman plots. Mean ± 1.96 SD was used as a reference range. Mean native T1 and T2 values were 1200.1 ± 30.7 ms and 39.5 ± 1.8 ms, respectively. There was no significant bias in repeated measurements by the same and different observers. For the first time in Malta, we established the native T1 and T2 parametric mapping reference values for healthy Caucasian Maltese individuals. This will assist cardiologists to establish diagnosis, disease progression, and response to treatment of various myocardial diseases locally.

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Above listed authors take responsibility for all aspects of the reliability and freedom from bias of the data presented and their discussed interpretation.This work has not been presented elsewhere.

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Funding

The authors received no financial support for the research authorship, and/or publication of this article.

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Authors and Affiliations

  1. Department of Cardiology, Mater Dei Hospital, Triq Dun Karm, Cardiac Medical Ward, L-Imsida, MSD2090, Malta

    Kentaro Yamagata, Lara Marie Yamagata, Mark Abela & Alexander Borg

  2. Department of Radiology, Mater Dei Hospital, L-Imsida, Malta

    Claude Portanier Mifsud, Lee Ann Micallef & Luise Reichmuth

Authors
  1. Kentaro Yamagata
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  2. Lara Marie Yamagata
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  3. Mark Abela
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  4. Claude Portanier Mifsud
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  5. Lee Ann Micallef
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  6. Luise Reichmuth
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  7. Alexander Borg
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Contributions

K.Y. and L.M.Y. organized a whole study, wrote the main manuscript text and prepared figures and tables. M.A. and A.B. contributed in statistical analysis and reviewed the main manuscript text. C.P.M. and L.M. collected data. L.R. helped recruiting subjects.

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Correspondence to Kentaro Yamagata.

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The authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

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Yamagata, K., Yamagata, L.M., Abela, M. et al. Native T1 and T2 reference values for maltese healthy cohort. Int J Cardiovasc Imaging 39, 153–159 (2023). https://doi.org/10.1007/s10554-022-02709-6

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  • DOI: https://doi.org/10.1007/s10554-022-02709-6

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