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Evaluation of left atrial reservoir function and sphericity index in patients with mitral valve disease: a cardiac magnetic resonance imaging study

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Abstract

To assess the performance of biplane area-length method in measuring left atrial (LA) volume and sphericity index and to investigate the correlation of LA reservoir function and sphericity index with atrial fibrosis on cardiac magnetic resonance imaging (MRI) in patients with mitral valve disease (MVD). Forty-eight patients with MVD undergoing cardiac MRI scan were enrolled in this retrospective study. LA reservoir function, measured as maximum volume (LAVmax), minimum volume (LAVmin) and ejection fraction (LAEF), and sphericity index were quantified using the biplane area-length method and standard short-axis approach, respectively. Comparisons of LA reservoir function and sphericity index between the two different methods were performed, as well as between positive (n = 17, 35%) and negative atrial wall fibrosis groups (n = 31, 65%). There was no difference in the values of LAVmax index and sphericity index between the two different methods. The biplane area-length method had poor performance in assessing LAVmin index and LAEF compared to standard short-axis approach, with an underestimation of 13.5% for LAVmin index and an overestimation of 27% for LAEF. Patients with positive atrial fibrosis had larger LAVmax index, LAVmin index and sphericity index, and lower LAEF levels in comparison to the negative atrial fibrosis group. The biplane area-length method has good performance in assessing LA sphericity index for patients with MVD, not in LA reservoir function. Patients with positive atrial fibrosis tend to suffer from more adverse LA remodelling.

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Acknowledgements

This work was supported by the Key Research and Development Program of Liaoning Province, China (Grant Numbers 2018225024 and 2020JH2/10300119).

Funding

This work was supported by the Key Research and Development Program of Liaoning Province, China (Grant Numbers 2018225024 and 2020JH2/10300119).

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Authors and Affiliations

  1. College of Medicine and Biological Information Engineering, Northeastern University, Shenyang, China

    Yu Sun & Jie Hou

  2. Department of Radiology, General Hospital of Northern Theater Command, 83 Wenhua Road, Shenyang, 110016, Liaoning Province, People’s Republic of China

    Yu Sun, Jie Hou, Xiao-gang Li, Ming-yu Zou, Wei Wang, Li-bo Zhang & Ben-qiang Yang

  3. Key Laboratory of Cardiovascular Imaging and Research of Liaoning Province, Shenyang, China

    Yu Sun, Jie Hou, Xiao-gang Li, Ming-yu Zou, Wei Wang, Li-bo Zhang & Ben-qiang Yang

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  1. Yu Sun
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  5. Wei Wang
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Contributions

All authors contributed to the study conception and design. Material preparation, data collection and analysis were performed by YS, JH, XL, MZ and WW. The first draft of the manuscript was written by YS. Professors LiZ and BY commented on previous versions of the manuscript. All authors read and approved the final manuscript.

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Correspondence to Ben-qiang Yang.

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The authors have no relevant financial or non-financial interests to disclose.

Ethical approval

This study was performed in line with the principles of the Declaration of Helsinki. Approval was granted by the Ethics Committee of the General Hospital of Northern Theater Command (Data: 2021-03-31/No. Y [2021]037).

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Informed consent was waived by the committee because of the retrospective nature of this study.

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Sun, Y., Hou, J., Li, Xg. et al. Evaluation of left atrial reservoir function and sphericity index in patients with mitral valve disease: a cardiac magnetic resonance imaging study. Int J Cardiovasc Imaging 38, 2425–2435 (2022). https://doi.org/10.1007/s10554-022-02654-4

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