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Diffusion-weighted imaging in hypertrophic cardiomyopathy: association with high T2-weighted signal intensity in addition to late gadolinium enhancement

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Abstract

Diffusion-weighted imaging (DWI) has been confirmed to be associated with late gadolinium enhancement (LGE) in hypertrophic cardiomyopathy (HCM). In this context, we aimed to study whether DWI could reflect the active tissue injury and edema information of HCM which were usually indicated by T2 weighted images. Forty HCM patients were examined using a 3.0 T magnetic resonance scanner. Cine, T2-weighted short tau inversion recovery (T2-STIR), DWI and LGE sequences were acquired. T1 mapping was also included to quantify the focal and diffuse fibrosis. Cardiac troponin I (cTnI) was tested to assess the recently myocardial injury. Student’s t-test, Mann–Whitney U test, One-way analysis, Kruskal–Wallis analysis, the Spearman correlation analysis, and multivariable regression were used in this study. The apparent diffusion coefficient (ADC) was significantly elevated in the cTnI positive group (P = 0.01) and correlated with LGE (ρ = 0.312, P = 0.049) and HighT2 extent (ρ = 0.443, P = 0.004) in the global level. In the segmental analysis, the ADC significantly differentiated the segments with and without HighT2/LGE presence (P = 0.00). The average ADC values were higher in segments with HighT2 and LGE coexistence than in those with only LGE presence (P < 0.05). Multivariable regression indicated that segmental HighT2 and LGE were both contributing factors to the ADC values. In this study of HCM, we confirmed that ADC as a molecular diffusion parameter reflects the replacement fibrosis of myocardium. Moreover, it also reveals edema extent and its association with serum cTnI.

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Acknowledgements

Ruo-yang Shi and Dong-aolei An contributed equally to this work.

Funding

National Natural Science Foundation of China (Grant Nos.81873886 and 81873887), Shanghai Municipal Commission of Health and Family Planning excellent young talent program (Grant No. 2017YQ031), Shanghai Jiao Tong University medical cross project (Grant No. YG2017QN44), Shanghai Shenkang Hospital Development Center Clinical Research and Cultivation Project (Grant No. SHDC12018X21), Shanghai Science and technology innovation action plan, technology standard project Grant numbers: (Grant No. 19DZ2203800).

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Authors and Affiliations

  1. Department of Radiology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, No. 160, Pujian Road, Shanghai, 200127, China

    Ruo-yang Shi, Dong-aolei An, Bing-hua Chen, Rui Wu, Jian-rong Xu & Lian-ming Wu

  2. Robotics Institute, Shanghai Jiao Tong University, Shanghai, China

    Liang Du

  3. Department of Cardiology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China

    Meng Jiang

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Shi, Ry., An, Da., Chen, Bh. et al. Diffusion-weighted imaging in hypertrophic cardiomyopathy: association with high T2-weighted signal intensity in addition to late gadolinium enhancement. Int J Cardiovasc Imaging 36, 2229–2238 (2020). https://doi.org/10.1007/s10554-020-01933-2

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