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Neointimal characteristics comparison between biodegradable-polymer and durable-polymer drug-eluting stents: 3-month follow-up optical coherence tomography light property analysis from the RESTORE registry

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Abstract

We aimed to quantitatively assess a possible difference of the neointimal quality between biodegradable polymer- (BP-) and durable polymer drug-eluting stents (DP-DESs). We conducted a single-center all-comer prospective cohort study: the RESTORE registry (UMIN000033009). All patients who received successful OCT examination at planned 3-month follow-up after DES implantation were analyzed. Study population was divided into 2 groups, BP-DES versus DP-DES groups. We evaluated standard OCT variables, coverage percent, and the quantitative light property values including light intensity, attenuation, and backscatter. We performed OCT analyses of 121 lesions in 98 patients (BP-DES 55 lesions in 51 patients vs. DP-DES 66 lesions in DP-DES 53 patients). Lesion and procedural characteristics were overall well-balanced between both groups. At 3-month follow-up, neointimal thickness (BP-DES 49.3 [38.2, 57.7] µm versus DP-DES 54.7 [45.1, 70.7] µm, p = 0.059) and coverage percent (BP-DES 94.5 [89.8, 97.0]% vs. DP-DES 95.8 [91.1, 98.1]%, p = 0.083) did not significantly differ. Light intensity of superficial neointima in the BP-DES was lower than that in the DP-DES, whereas that of deep neointima did not differ between both groups. Both superficial and deep neointima of the BP-DES presented significantly lower light attenuation and backscatter than those of the DP-DES did. Almost complete coverage at 3 months in both contemporary BP- and DP-DES would support the ultra-short DAPT strategy in the upcoming decade. Nevertheless, there was a significant difference in the neointimal characteristics on OCT light property 3 months after BP- versus DP-DES implantation.

Trial Registration UMIN000033009.

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Authors and Affiliations

  1. Department of Cardiology, Osaka Police Hospital, 10-31, Kitayama, Tennoji, Osaka, 543-0035, Japan

    Tomoaki Kobayashi, Yohei Sotomi, Satoshi Suzuki, Yuma Hamanaka, Shimpei Nakatani, Atsushi Hirayama & Yoshiharu Higuchi

  2. Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands

    Jouke Dijkstra

  3. Thoraxcenter, Erasmus Medical Center, Rotterdam, The Netherlands

    Yoshinobu Onuma

  4. Cardialysis, Rotterdam, The Netherlands

    Yoshinobu Onuma

  5. International Centre for Circulatory Health, NHLI, Imperial College London, London, UK

    Patrick W. Serruys

  6. Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, Osaka, Japan

    Yasushi Sakata

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  1. Tomoaki Kobayashi
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Correspondence to Yohei Sotomi.

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Conflict of interest

Y. Sotomi, S. Nakatani, and Y. Higuchi received speaker honoraria from Abbott Vascular Japan, Boston Scientific Japan, TERUMO, Cardinal Health, and Medtronic. Y. Onuma and P. Serruys are members of the Advisory Board for Abbott Vascular.A. Hirayama reports grants and personal fees from Boston Scientific Japan, Abbott Vascular Japan, Japan Lifeline, and Medtronic. Y. Sakata reports grants and personal fees from Daiichi-Sankyo, Bayer, Boehringer Ingelheim, and Bristol-Myers Squibb. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.

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Kobayashi, T., Sotomi, Y., Suzuki, S. et al. Neointimal characteristics comparison between biodegradable-polymer and durable-polymer drug-eluting stents: 3-month follow-up optical coherence tomography light property analysis from the RESTORE registry. Int J Cardiovasc Imaging 36, 205–215 (2020). https://doi.org/10.1007/s10554-019-01718-2

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