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Correlation between left ventricular myocardial strain and left ventricular geometry in healthy adults: a cardiovascular magnetic resonance-feature tracking study

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Abstract

This study was aimed to investigate the correlation between left ventricular (LV) myocardial strain and LV geometry in healthy adults using cardiovascular magnetic resonance-feature tracking (CMR-FT). 124 gender-matched healthy adults who underwent healthy checkup using CMR cine imaging were retrospectively analyzed. Peak global radial, circumferential, longitudinal strain (GRS, GCS and GLS) for left ventricle were measured. LV geometry was assessed by the ratio of LV mass (LVM) and end-diastolic volume (EDV). GRS, GCS and GLS were 34.18 ± 6.71%, − 22.17 ± 2.28%, − 14.76 ± 2.39% for men, and 33.40 ± 6.95%, − 22.49 ± 2.27%, − 15.72 ± 2.36% for women. Multiple linear regression showed that LVM/EDV was associated with decreased GLS (β = − 0.297, p = 0.005), but was not significantly associated with GRS and GCS (both p > 0.05). There was an increase in the magnitude of GRS, GCS and GLS with advancing age (β = 0.254, β = 0.466 and β = 0.313, all p < 0.05). Greater BMI was associated with decreased GRS, GCS and GLS (β = − 0.232, β = − 0. 249 and β = − 0.279, all p < 0.05). In conclusion, compared with GRS and GCS, GLS is more sensitive to assess LV concentric remodeling in healthy adults. GRS, GCS and GLS are all independently positively associated with age and negatively associated with BMI. Sex-based LV strain reference values for healthy Chinese adults are established.

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Authors and Affiliations

  1. Department of Radiology, Xuanwu Hospital, Capital Medical University, No. 45 Changchun Street, Xicheng District, Beijing, 100053, China

    Zhen Zhang, Lizhen Cao & Kuncheng Li

  2. Department of Magnetic Resonance, the Third Medical Centre, Chinese People’s Liberation Army General Hospital, Beijing, China

    Qiaozhi Ma

  3. Xiamen Zhouxin Medical Imaging Diagnostic Centre, Xiamen, China

    Zhiwei Zhao, Jun Zhao, Qing Lu, Linan Zeng, Mingzhu Zhang, Gerald M. Pohost & Kuncheng Li

  4. Keck School of Medicine, University of Southern California, Los Angeles, CA, USA

    Gerald M. Pohost

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  1. Zhen Zhang
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Zhang, Z., Ma, Q., Cao, L. et al. Correlation between left ventricular myocardial strain and left ventricular geometry in healthy adults: a cardiovascular magnetic resonance-feature tracking study. Int J Cardiovasc Imaging 35, 2057–2065 (2019). https://doi.org/10.1007/s10554-019-01644-3

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