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Less pronounced reverse left ventricular remodeling in patients with bicuspid aortic stenosis treated with transcatheter aortic valve replacement compared to tricuspid aortic stenosis

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Abstract

To compare reverse left ventricular (LV) remodeling after transcatheter aortic valve replacement (TAVR) between patients with bicuspid aortic valve (BAV) and tricuspid aortic valve (TAV). We retrospectively reviewed data of patients with at least two serial echocardiographic follow-ups (1, 3, 6 months and 1 year) post-TAVR. A total of 116 patients were identified. BAV morphology was documented in 67 patients. LV mass index (LVMi) at baseline was not significantly different between the TAV and BAV group (178.0 ± 6.9 vs. 166.3 ± 6.4 g/m2, P = 0.14). Reverse LV remodeling was observed in both BAV and TAV patients, but the reduction of LVMi from baseline was significantly more pronounced in TAV patients compared with BAV patients from 6 months post-TAVR (− 56.3 ± 8.1 vs. − 30.0 ± 4.7 g/m2, P < 0.01 at 6-month follow-up; − 60.6 ± 7.6 vs. − 37.9 ± 6.2 g/m2, P = 0.02 at 1-year follow-up). EDV value changes during follow-up were similar between patient with TAV and BAV. There were no significant differences in the proportions of patients with more than mild PVL or new permanent pacemaker between TAV and BAV morphology throughout the follow-up. Patients with bicuspid morphology might experience less pronounced reverse LV remodeling post-TAVR than patients with tricuspid morphology.

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Acknowledgements

This work was supported by National Natural Science Foundation of China (81370219, Beijing, China); Science and Technology Support Plan of Sichuan province (2016FZ0078); Science and Technology Innovative Research Groups Program of Sichuan province (2017TD0004); “13th Five-Year” National key Research and Development Program of China (2016YFC1102200); West China Hospital “1·3·5” Discipline of Excellence Project-Percutaneous transcatheter aortic valve implantation.

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Author notes

  1. Tian-Yuan Xiong and Xi Wang have contributed equally to this study.

Authors and Affiliations

  1. Department of Cardiology, West China Hospital, Sichuan University, #37 Guoxue Alley, Chengdu, 610041, People’s Republic of China

    Tian-Yuan Xiong, Xi Wang, Yi-Jian Li, Yan-Biao Liao, Zhen-Gang Zhao, Xin Wei, Yuan-Ning Xu, Ming-Xia Zheng, Yong Peng, Jia-Fu Wei, Yuan Feng & Mao Chen

  2. Department of Radiology, West China Hospital, Sichuan University, Chengdu, People’s Republic of China

    Xuan Zhou

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  1. Tian-Yuan Xiong
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Correspondence to Mao Chen.

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M. Chen and Y. Feng are consultants/proctors of Venus MedTech and MicroPort. The other authors do not have disclosures.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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Informed consent was obtained from all individual participants included in the study.

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Xiong, TY., Wang, X., Li, YJ. et al. Less pronounced reverse left ventricular remodeling in patients with bicuspid aortic stenosis treated with transcatheter aortic valve replacement compared to tricuspid aortic stenosis. Int J Cardiovasc Imaging 34, 1761–1767 (2018). https://doi.org/10.1007/s10554-018-1401-6

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  • DOI: https://doi.org/10.1007/s10554-018-1401-6

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