Detection of myocardial iron overload by two-dimensional speckle tracking in patients with beta-thalassaemia major: a combined echocardiographic and T2* segmental CMR study

  • Fausto Pizzino
  • Antonella Meloni
  • Anna Terrizzi
  • Tommaso Casini
  • Anna Spasiano
  • Carlo Cosmi
  • Massimo Allò
  • Concetta Zito
  • Scipione Carerj
  • Giovanni Donato Aquaro
  • Gianluca Di Bella
  • Alessia Pepe
Original Paper

Abstract

We aimed to evaluate the role of two-dimensional speckle tracking imaging (2DSTI) in detecting early changes of myocardial deformation in patients affected by thalassemia major (TM) and its relation with myocardial iron overload (MIO) detected by T2* cardiovascular magnetic resonance (CMR). We studied 28 TM patients (15 males, 37.4 ± 10 years). All patients underwent CMR and echocardiography in the same day. Segmental and global T2* values were measured. Values of global longitudinal strain (GLS) were derived from the three apical views, while radial and circumferential strain were obtained as average strain from the short axis views at basal, mid and apical level. Six patients (21.4%) showed significant MIO (global heart T2* < 20 ms). GLS showed a significant correlation with T2* values (R = −0.49; P = 0.001) and it was significantly lower in patients with a significant MIO than in those with no significant MIO (−18.3 ± 2 vs. −21.3 ± 2.7, P = 0.02). No significant difference was found for radial and circumferential strain in relation to the severity of MIO. Patients with impaired GLS (<−19.5%) had a significant higher risk of showing significant MIO (Odds-ratio-OR = 17; 95%). GLS is related with global T2* in TM patients. Moreover, GLS can identify TM patients with severe MIO detected by CMR.

Keywords

Thalassemia major Myocardial deformation Myocardial iron overload 

Notes

Acknowledgements

We thank all patients for their cooperation. We also thank the technical radiologists, the nurses and the secretary for their support in this study.

Compliance with ethical standards

Conflict of interest

The authors do not have any conflict of interest to declare.

Funding

The MIOT project received ‘no-profit support’ from Chiesi Farmaceutici S.p.A., Apopharma Inc and Bayer S.P.A.

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Copyright information

© Springer Science+Business Media B.V. 2017

Authors and Affiliations

  • Fausto Pizzino
    • 1
    • 2
    • 3
  • Antonella Meloni
    • 2
  • Anna Terrizzi
    • 1
  • Tommaso Casini
    • 4
  • Anna Spasiano
    • 5
  • Carlo Cosmi
    • 6
  • Massimo Allò
    • 7
  • Concetta Zito
    • 1
  • Scipione Carerj
    • 1
  • Giovanni Donato Aquaro
    • 2
  • Gianluca Di Bella
    • 1
  • Alessia Pepe
    • 2
  1. 1.Dipartimento di Medicina Clinica e SperimentaleUniversità di Messina, AOU “Policlinico G. Martino”MessinaItaly
  2. 2.Magnetic Resonance Imaging UnitFondazione G. Monasterio CNR-Regione ToscanaPisaItaly
  3. 3.Medical and Surgical Pathologies of the Heart UnitFondazione G. Monasterio CNR-Regione ToscanaMassaItaly
  4. 4.Centro Talassemie ed EmoglobinopatieOspedale “Meyer”FirenzeItaly
  5. 5.U.O.S.D. Centro per le MicrocitemieAORN CardarelliNapoliItaly
  6. 6.Clinica PediatricaAzienda Ospedaliero-Universitaria di SassariSassariItaly
  7. 7.Servizio MicrocitemiaPresidio Ospedaliero ASL 5CrotoneItaly

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