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Echocardiographic and hemodynamic assessment for predicting early clinical events in severe acute mitral regurgitation

  • Shin Watanabe
  • Kenneth Fish
  • Guillaume Bonnet
  • Carlos G. Santos-Gallego
  • Lauren Leonardson
  • Roger J. Hajjar
  • Kiyotake Ishikawa
Original Paper

Abstract

The diagnostic role of echocardiographic and hemodynamic assessment in acute mitral regurgitation (AMR) remains unclear. The central question of this study was to determine if echocardiographic and hemodynamic parameters can predict early clinical events in AMR. AMR was induced by percutaneously severing the mitral valve chordae tendineae in 39 Yorkshire pigs. Immediately after AMR induction, echocardiographic and hemodynamic exams were performed, and compared between those who died and those who survived within 30-days of the procedure. Echocardiographic indices of MR severity as well as the left atrial pressure showed significant differences between survivors and non-survivors in univariate analysis. Multi-variate logistic regression analysis revealed that echocardiography-derived regurgitant fraction and vena contracta as well as mean left atrial pressure could be used to segment the cohort into survivors and non-survivors. Our study demonstrated, for the first time, that echocardiographic and hemodynamic assessment of AMR provides predictive information on early clinical events in a clinically relevant animal model of AMR.

Keywords

Acute heart failure MR Pig model 

Notes

Acknowledgements

This study was supported by NIH P50 HL112324, R01 HL119046, R01 HL117505, R01HL128099, R01 HL129814, R01HL131404, & R43HL108581 (R. J. H.), and a Transatlantic Leducq Foundation grant. We would like to acknowledge the Gene Therapy Resource Program (GTRP) of the National Heart, Lung, and Blood Institute, National Institutes of Health. K. I. is supported by a Grant from American Heart Association 17SDG33410873. G. B. was supported by the French Federation of Cardiology.

Compliance with Ethical Standards

Conflict of interest

None.

Supplementary material

10554_2017_1215_MOESM1_ESM.pdf (7 kb)
Supplementary material 1 (PDF 7 KB)

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Copyright information

© Springer Science+Business Media B.V. 2017

Authors and Affiliations

  • Shin Watanabe
    • 1
  • Kenneth Fish
    • 1
  • Guillaume Bonnet
    • 1
  • Carlos G. Santos-Gallego
    • 1
  • Lauren Leonardson
    • 1
  • Roger J. Hajjar
    • 1
  • Kiyotake Ishikawa
    • 1
  1. 1.Cardiovascular Research CenterIcahn School of Medicine at Mount SinaiNew YorkUSA

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