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Prolonged QTc indicates the clinical severity and poor prognosis in patients with isolated left ventricular non-compaction

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Abstract

Isolated left ventricular non-compaction (LVNC) is a rare cardiomyopathy that leads to severe clinical complications. This study is to investigate whether or not prolonged QTc is a good indicator for evaluating the severity of fibrosis and predicting the prognosis of LVNC, and if native T1 can be used to quantify the fibrosis. 32 LVNC patients and 14 healthy controls with matched age and sex were examined by CMR and ECG to acquire native T1, QTc interval, and ECG abnormalities. 18 LVNC patients had normal QTc and 14 LVNC patients had prolonged QTc. The mean native T1 value of the normal controls, normal QTc and prolonged QTc patients was 1096.0 ± 41.5, 1141.98 ± 45.46, and 1182.67 ± 42.02 ms, respectively. One-way ANVOA showed significant differences in native T1 among three groups (F = 14.9, p < 0.001). In LVNC patients, the QTc interval significantly correlated with LVEF (p = 0.003, r = 0.51) and native T1 values (p = 0.015, R = −0.47). This suggests that prolonged QTc is associated with more severe compacted myocardial fibrosis, more cardiac dysfunction, and a poorer prognosis in LVNC patients. Follow-up data showed significant differences in adverse events between patients with normal QTc and patients with prolonged QTc (p = 0.036). Prolonged QTc interval leads to more severe compacted myocardial fibrosis, poorer cardiac dysfunction, and poorer prognosis in LVNC patients.

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Funding

This study was supported by Key Projects in Chinese National Science & References Technology Pillar Program during the Twelfth Five-year Plan Period (2011BAI11B11) and National Natural Science Foundation of China (81271536, 81670349).

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Authors and Affiliations

  1. Department of Cardiology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, 160 Pujian Rd, Pudong New District, Shanghai, 200127, China

    Hongmei Zhou, Meng Jiang, Heng Ge & Ben He

  2. Department of Cardiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, No.1 Shuaifuyuan, Wangfujing, Dongcheng District, Beijing, 100730, China

    Xue Lin, Ligang Fang, Wenlin Zhu & Quan Fang

  3. Department of Biomedical Engineering, Center for Biomedical Imaging Research, Tsinghua University School of Medicine, Beijing, China

    Xihai Zhao & Haiyan Ding

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  1. Hongmei Zhou
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  2. Xue Lin
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  3. Ligang Fang
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  4. Wenlin Zhu
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  9. Quan Fang
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  10. Ben He
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Correspondence to Quan Fang or Ben He.

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Zhou, H., Lin, X., Fang, L. et al. Prolonged QTc indicates the clinical severity and poor prognosis in patients with isolated left ventricular non-compaction. Int J Cardiovasc Imaging 33, 2013–2020 (2017). https://doi.org/10.1007/s10554-017-1209-9

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  • DOI: https://doi.org/10.1007/s10554-017-1209-9

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