SASHA versus ShMOLLI: a comparison of T1 mapping methods in health and dilated cardiomyopathy at 3 T

  • Benedict T. Costello
  • Fabian Springer
  • James L. Hare
  • Andre La Gerche
  • Leah Iles
  • Andris H. Ellims
  • Benjamin Schmitt
  • Andrew J. Taylor
Original Paper


Cardiac Magnetic Resonance derived T1 mapping parameters are a non-invasive method of estimating diffuse myocardial fibrosis. This study aims to to determine the native T1 time, post contrast T1 time and extracellular volume (ECV) derived from T1 mapping and to evaluate the ability of T1 mapping techniques to discriminate healthy myocardium from dilated cardiomyopathy. Seventy-nine participants underwent cardiac magnetic resonance imaging at the Baker Heart and Diabetes Institute, Melbourne, Australia. Fifty-seven healthy volunteers and twenty-two patients with Dilated cardiomyopathy were included in the study. Each participant had T1 mapping sequences performed at 3 T in the mid short axis slice—both SASHA and ShMOLLI T1 mapping were performed. Native T1, post contrast T1 and ECV values were compared in health and dilated cardiomyopathy. Native T1, post contrast T1 and ECV differed significantly between SASHA and ShMOLLI techniques (P < 0.001). All T1 parameters had similar ability to discriminate normal from abnormal myocardium (ROC AUC 0.691 to 0.830). Converting T1 values to Z scores significantly improved the agreement between SASHA and ShMOLLI techniques, particularly for post contrast T1 (ICC 0.19 to 0.895) and ECV (ICC 0.461 to 0.880). T1 mapping values from SASHA and ShMOLLI show strong correlation for post contrast measures, though with a consistent offset for all measures in health and dilated cardiomyopathy. All measures obtained using SASHA and ShMOLLI allow good discrimination between dilated cardiomyopathy and normal myocardium.


Cardiac magnetic resonance Cardiomyopathy T1 mapping Fibrosis 



Saturation recovery single shot acquisition


Modified look locker


Shortened modified look locker


Cardiac magnetic resonance


Extracellular volume


3 Tesla


Left ventricular ejection fraction


Dilated cardiomyopathy


Estimated glomerular filtration rate


Short axis


Receiver operator characteristic


Area under curve


Standard deviation


Intraclass correlation coefficient



We thank the Baker IDI Heart and Diabetes Institute radiology staff for their assistance in this project.


AJT is supported by a National Health and Medical Research Council project grant.

Author contributions

BC—conception, design and analysis and interpretation of data, and drafting of the manuscript; FS—analysis of data and revision of the manuscript; JH—conception and design and revision of the manuscript; ALG—analysis and interpretation of data, revision of manuscript; LI—revision of manuscript; AE—revision of manuscript; BS—revision of manuscript and technical advice; AJT—conception, design and analysis and interpretation of data, revision of the manuscript and final approval.

Compliance with ethical standards

Conflict of interest

Benjamin Schmitt is an employee of Siemens Healthineers.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. The study was approved by the Alfred Hospital Ethics Committee (Melbourne, Australia) and carried out under their guidelines. Prior to inclusion in the study written informed consent was obtained from all participants.

Availability of supporting data

The anonymized datasets analyzed during the current study are available from the corresponding author, on reasonable request.

Supplementary material

10554_2017_1134_MOESM1_ESM.docx (25 kb)
Supplementary material 1 (DOCX 25 KB)


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Copyright information

© Springer Science+Business Media Dordrecht 2017

Authors and Affiliations

  • Benedict T. Costello
    • 1
    • 2
  • Fabian Springer
    • 1
    • 2
  • James L. Hare
    • 1
    • 2
  • Andre La Gerche
    • 1
    • 2
  • Leah Iles
    • 1
    • 2
  • Andris H. Ellims
    • 1
    • 2
  • Benjamin Schmitt
    • 3
  • Andrew J. Taylor
    • 1
    • 2
    • 4
  1. 1.The Alfred HospitalMelbourneAustralia
  2. 2.Baker Heart and Diabetes InstituteMelbourneAustralia
  3. 3.Siemens HealthineersErlangenGermany
  4. 4.Heart CentreMelbourneAustralia

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