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Intermediate CD14++CD16+ monocyte predicts severe coronary stenosis and extensive plaque involvement in asymptomatic individuals

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Abstract

Circulating leukocyte subtypes and monocyte subsets are independent predictors of cardiovascular events. We hypothesized that an increased leukocyte subtype would predict severe coronary stenosis and extensive plaque involvement. We retrospectively analyzed clinical, laboratory, and coronary CT data in a total of 588 asymptomatic adults (69% men; mean age, 57 ± 9 years) undergoing a general health check-up. Intermediate CD14++CD16+ monocyte count had the strongest association with mixed and calcified plaque scores, whereas the numbers of neutrophils and classical CD14++CD16− monocytes were significantly associated with non-calcified plaque score. Only high CD14++CD16+ monocyte count (>12 cells/μL) significantly predicted extensive plaque involvement [odds ratio 3.16 (95% confidence interval 1.84–5.43), P < 0.001; quartile 4 vs. 1–3] and severe coronary stenosis [3.67 (1.84–7.33), P < 0.001; quartile 4 vs. 1–3] after adjustments for Framingham Risk Score (FRS), metabolic syndrome, and C-reactive protein. The CD14++CD16+ monocyte count, when added to FRS, significantly reclassified 30.4 and 26.7% of the overall and 50.2 and 36.2% of the intermediate-risk population (FRS 6–20%) for predicting extensive plaque involvement and severe coronary stenosis, respectively. Thus, in asymptomatic individuals, intermediate CD14++CD16+ monocyte could independently predict severe CAD and improve risk stratification.

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Acknowledgements

This study was funded by the National Taiwan University Hospital (NTUH.100-S1611). The authors appreciate the help of the staff of the Health Management Center at National Taiwan University Hospital and thank Rong Ling Hung for her help in the flow cytometric analyses.

Funding

This study was funded by the National Taiwan University Hospital (NTUH.100-S1611).

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Authors and Affiliations

  1. Department of Laboratory Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan

    Shyh-Chyi Lo

  2. Department of Medical Imaging, National Taiwan University Hospital, Taipei, Taiwan

    Wen-Jeng Lee

  3. Department of Radiology, National Taiwan University College of Medicine, Taipei, Taiwan

    Wen-Jeng Lee

  4. Department of Medical Imaging, National Taiwan University Hospital Hsin-Chu Branch, Hsinchu, Taiwan

    Wen-Jeng Lee

  5. Department of Animal Science and Technology, National Taiwan University, Taipei, Taiwan

    Ching-Yi Chen

  6. Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, 7 Chung-Shan South Road, Taipei, Taiwan

    Bai-Chin Lee

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Correspondence to Bai-Chin Lee.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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Lo, SC., Lee, WJ., Chen, CY. et al. Intermediate CD14++CD16+ monocyte predicts severe coronary stenosis and extensive plaque involvement in asymptomatic individuals. Int J Cardiovasc Imaging 33, 1223–1236 (2017). https://doi.org/10.1007/s10554-017-1097-z

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  • DOI: https://doi.org/10.1007/s10554-017-1097-z

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