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Left ventricular filling pressure by septal and lateral E/e′ equally predict cardiovascular events in the general population

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Abstract

Purpose: There exists no consensus on the site of E/e′ measurement. This study aimed to evaluate the predictive value of septal and lateral E/e′ along with the importance of their intra-individual difference. Methods: In 1775 persons from the general population, peak early diastolic velocity (e′) was obtained by color tissue Doppler at the septal and lateral mitral annular sites. The endpoint was combined of cardiovascular death or admission due to heart failure or acute myocardial infarction. Results: During a median follow-up of 10.9 years, the endpoint occurred in 227 participants. E/e′septal and E/e′lateral were equally strong predictors of cardiac events; in age- and sex-adjusted models they did not differ in AUC (septal: 0.8385, lateral: 0.8389; p = 0.94) or in continuous NRI (p = 0.84). Models using E/e′average did not improve AUC or NRI, and the intra-individual difference between sites had no predictive value (p = 0.79). E/e′septal was generally higher than E/e′lateral, thus age- and sex-specific normal values were reported for both sites for a population free of cardiac events during 10 years of follow-up. Conclusions: Septal and lateral E/e′ are equally useful in predicting cardiac events in the general population. Measuring both sites provides no further predictive value than measuring a single site.

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Acknowledgements

This study was funded by the Danish Council for Independent Research (DFF-4183-00499).

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Authors and Affiliations

  1. Copenhagen City Heart Study, Frederiksberg Hospital, University of Copenhagen, Frederiksberg, Denmark

    Joanna Nan Wang, Tor Biering-Sørensen, Peter Godsk Jørgensen, Jan Skov Jensen & Rasmus Mogelvang

  2. Department of Cardiology, Herlev and Gentofte Hospital, University of Copenhagen, Post 835, Kildegaardsvej 28, 2900, Hellerup, Denmark

    Joanna Nan Wang, Tor Biering-Sørensen, Peter Godsk Jørgensen & Jan Skov Jensen

  3. Faculty of Health Sciences, Institute of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark

    Jan Skov Jensen

  4. Department of Cardiology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark

    Rasmus Mogelvang

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  1. Joanna Nan Wang
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  2. Tor Biering-Sørensen
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  3. Peter Godsk Jørgensen
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  4. Jan Skov Jensen
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Correspondence to Joanna Nan Wang.

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Investigations were carried out at the Copenhagen City Heart Study.

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Wang, J.N., Biering-Sørensen, T., Jørgensen, P.G. et al. Left ventricular filling pressure by septal and lateral E/e′ equally predict cardiovascular events in the general population. Int J Cardiovasc Imaging 33, 653–661 (2017). https://doi.org/10.1007/s10554-016-1052-4

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  • DOI: https://doi.org/10.1007/s10554-016-1052-4

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