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Left ventricular wall thickness in patients with hypertrophic cardiomyopathy: a comparison between cardiac magnetic resonance imaging and echocardiography

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Abstract

We assessed whether cardiac MRI (CMR) and echocardiography (echo) have significant differences measuring left ventricular (LV) wall thickness (WT) in hypertrophic cardiomyopathy (HCM) as performed in the clinical routine. Retrospectively identified, clinically diagnosed HCM patients with interventricular-septal (IVS) pattern hypertrophy who underwent CMR and echo within the same day were included. Left Ventricular WT was measured by CMR in two planes and compared to both echo and contrast echo (cecho). 72 subjects, mean age 50.7 ± 16.2 years, 68 % males. Interventricular septal WT by echo and CMR planes showed good to excellent correlation. However, measurements of the postero-lateral wall showed poor correlation. Bland–Altman plots showed greater maximal IVS WT by echo compared to CMR measurement [SAX = 1.7 mm (−5.8, 9.3); LVOT = 1.1 mm (−5.6, 7.8)]. Differences were smaller between cecho and CMR [SAX = 0.8 mm (−9.2, 10.8); LVOT = −0.2 mm (−10.0, 9.6)]. Severity of WT by quartiles showed greater differences between echo and SAX CMR WT compared to cecho. Echocardiography typically measures greater WT than CMR, with the largest differences in moderate to severe hypertrophy. Contrast echocardiography more closely approximates CMR measurements of WT. These findings have potential clinical implications for risk stratification of subjects with HCM.

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Abbreviations

Echo:

Echocardiography

Cecho:

Contrast echocardiography

LV:

Left ventricle

LVED:

LV end-diastolic

WT:

Wall thickness

HCM:

Hypertrophic cardiomyopathy

IVS:

Interventricular-septal

CMR:

Cardiac magnetic resonance imaging

LVOT:

LV outflow tract plane

SAX:

Short axis planes

LVIDd:

LV internal diastolic dimension

IVSd:

Inter-ventricular septum dimension

PWd:

Posterior wall dimension

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Authors and Affiliations

  1. The Russell H. Morgan Department of Radiology and Radiological Sciences, Johns Hopkins University School of Medicine, 601 North Caroline Street; JHOC 3142, Box 0818, Baltimore, MD, 21287, USA

    Celia P. Corona-Villalobos, Linda Chu, John Eng, Ihab R. Kamel & Stefan L. Zimmerman

  2. Division of Cardiology, Johns Hopkins University School of Medicine, Harvey 611, Baltimore, MD, 21287, USA

    Lars L. Sorensen, Iraklis Pozios, Maria Roselle Abraham & Theodore P. Abraham

Authors
  1. Celia P. Corona-Villalobos
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  2. Lars L. Sorensen
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  3. Iraklis Pozios
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  4. Linda Chu
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  5. John Eng
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  6. Maria Roselle Abraham
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  7. Theodore P. Abraham
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  8. Ihab R. Kamel
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  9. Stefan L. Zimmerman
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Correspondence to Stefan L. Zimmerman.

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The authors declare that they have no conflict of interest.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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Corona-Villalobos, C.P., Sorensen, L.L., Pozios, I. et al. Left ventricular wall thickness in patients with hypertrophic cardiomyopathy: a comparison between cardiac magnetic resonance imaging and echocardiography. Int J Cardiovasc Imaging 32, 945–954 (2016). https://doi.org/10.1007/s10554-016-0858-4

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  • DOI: https://doi.org/10.1007/s10554-016-0858-4

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