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Single breath hold 3D cardiac cine MRI using kat-ARC: preliminary results at 1.5T

The International Journal of Cardiovascular Imaging volume 31, pages 851–857 (2015)Cite this article

Abstract

Validation of a new single breath-hold, three-dimensional, cine balanced steady-state free precession (3D cine bSSFP) cardiac magnetic resonance (CMR) sequence for left ventricular function. CMR examinations were performed on fifteen patients and three healthy volunteers on a clinical 1.5T scanner using a two-dimensional (2D) cine balanced SSFP CMR sequence (2D cine bSSFP) followed by an investigational 3D cine bSSFP pulse sequence acquired within a single breath hold. Left ventricular end diastolic volume (LVEDV), end systolic volume (LVESV), ejection fraction (LVEF), and myocardial mass were independently segmented on a workstation by two experienced radiologists. Blood pool to myocardial contrast was evaluated in consensus using a Likert scale. Bland–Altman analysis was used to compare these quantitative and nominal measurements for the two sequences. The average acquisition time was significantly shorter for the 3D cine bSSFP than for 2D cine bSSFP (0.36 ± 0.03 vs. 8.5 ± 2.3 min) p = 0.0002. Bland–Altman analyses [bias and (limits of agreement)] of the data derived from these two methods revealed that the LVEF 0.9 % (−4.7, 6.4), LVEDV 4.9 ml (−23.0, 32.8), LVESV −0.2 ml (−22.4, 21.9), and myocardial mass −0.4 g (−23.8, 23.0) were not significantly different. There was excellent intraclass correlation for intra-observer variability (0.981, 0.989, 0.997, 0.985) and inter-observer variability (0.903, 0.954, 0.970, 0.842) for LVEF, LVEDV, LVESV, and myocardial mass respectively. 3D cine bSSFP allows for accurate single breath-hold volumetric cine CMR which enables substantial improvements in scanner time efficiency without sacrificing diagnostic accuracy.

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Affiliations

  1. Department of Radiology, University of Wisconsin-Madison School of Medicine and Public Health, University of Wisconsin-Madison, 600 Highland Avenue, Madison, WI, 53562, USA

    Daniel Jeong, Mark L. Schiebler, Karl K. Vigen & Christopher J. François

  2. Department of Radiology, Moffitt Cancer Center, Tampa, FL, USA

    Daniel Jeong

  3. Global MR Applications and Workflow, GE Healthcare, Menlo Park, CA, USA

    Peng Lai

  4. Global MR Applications and Workflow, GE Healthcare, Madison, WI, USA

    Kang Wang

  5. Department of Medicine, University of Wisconsin-Madison, Madison, WI, USA

    Christopher J. François

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  1. Daniel Jeong
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  2. Mark L. Schiebler
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  3. Peng Lai
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  4. Kang Wang
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  5. Karl K. Vigen
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  6. Christopher J. François
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Correspondence to Christopher J. François.

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Jeong, D., Schiebler, M.L., Lai, P. et al. Single breath hold 3D cardiac cine MRI using kat-ARC: preliminary results at 1.5T. Int J Cardiovasc Imaging 31, 851–857 (2015). https://doi.org/10.1007/s10554-015-0615-0

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  • DOI: https://doi.org/10.1007/s10554-015-0615-0

Keywords

  • Cardiac imaging techniques
  • Magnetic resonance imaging
  • Cine
  • Myocardium
  • Time
  • Ventricular function
  • Left