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Left and right atrial phasic function and deformation in untreated patients with prediabetes and type 2 diabetes mellitus

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Abstract

To evaluate phasic function and deformation of the left atrium (LA) and right atrium (RA) in subjects with prediabetes and type 2 diabetes mellitus. This cross-sectional study included 50 untreated normotensive subjects with prediabetes, 60 recently diagnosed normotensive diabetic patients and 60 healthy controls of similar sex and age. All the subjects underwent laboratory analyses and complete echocardiographic examination including strain analysis. LA and RA reservoir and conduit function gradually decreased, while booster pump increased, from the healthy controls, throughout the prediabetics, to the diabetics. The strain analysis of atrial phasic function showed more regular pattern of progressive atrial function deterioration than conventional evaluation with total, active and passive atrial function. In the whole study population HbA1c correlated with LA passive emptying fraction (r = −0.38, p < 0.01), LA active emptying fraction (r = 0.36, p < 0.01), LA longitudinal strain during systole (r = −0.35, p < 0.01), RA passive emptying fraction (r = −0.42, p < 0.01), RA active emptying fraction (r = 0.38, p < 0.01), and RA longitudinal strain during systole (r = −0.32, p < 0.01). However, only LA passive emptying fraction (β = −0.32, p < 0.01) and LA longitudinal strain during systole (β = −0.28, p = 0.02) were independently associated with HbA1c among the LA parameters; whereas solely RA passive emptying fraction (β = −0.37, p < 0.01) and RA active emptying fraction (β = 0.31, p = 0.01) were independently associated with HbA1c among the RA parameters. LA and RA phasic functions are significantly impaired in the prediabetics and the diabetics. The parameter of glucose control correlated with LA and RA reservoir, conduit and pump atrial function.

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Authors and Affiliations

  1. Department of Cardiology, University Clinical Hospital Center “Dr. Dragisa Misovic - Dedinje”, Heroja Milana Tepica 1, 11000, Belgrade, Serbia

    Marijana Tadic, Tamara Marjanovic, Vesna Kocijancic & Vera Celic

  2. Department of Endocrinology, University Clinical Hospital Center “Dr. Dragisa Misovic - Dedinje”, Heroja Milana Tepica 1, 11000, Belgrade, Serbia

    Sanja Ilic & Nada Kostic

  3. Clinical Research Unit, University of Milan-Bicocca and IstitutoAuxologico Italiano, Viale della Resistenza 23, 20036, Meda, Italy

    Cesare Cuspidi

  4. Department of Pharmacology, Faculty of Medicine, Doktora Subotica 2, 11000, Belgrade, Serbia

    Ljiljana Bukarica

  5. Clinic of Cardiology, Clinical Center of Serbia, Koste Todorovica 8, 11000, Belgrade, Serbia

    Branislava Ivanovic

  6. Faculty of Medicine, Doktora Subotica 6, 11000, Belgrade, Serbia

    Marijana Tadic, Branislava Ivanovic, Nada Kostic & Vera Celic

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  1. Marijana Tadic
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  2. Sanja Ilic
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Correspondence to Marijana Tadic.

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Tadic, M., Ilic, S., Cuspidi, C. et al. Left and right atrial phasic function and deformation in untreated patients with prediabetes and type 2 diabetes mellitus. Int J Cardiovasc Imaging 31, 65–76 (2015). https://doi.org/10.1007/s10554-014-0536-3

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  • DOI: https://doi.org/10.1007/s10554-014-0536-3

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