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Computed tomography for planning and postoperative imaging of transvenous mitral annuloplasty: first experience in an animal model

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Abstract

To investigate the use of computed tomography (CT) to measure the mitral valve annulus size before implantation of a percutaneous mitral valve annuloplasty device in an animal trial. Seven domestic pigs underwent CT before and after implantation of a Cardioband™ (a percutaneously implantable mitral valve annuloplasty device) with a second-generation 128-section dual-source CT machine. Implantation of the Cardioband™ was performed in a standard fashion according to a protocol. Animals were sacrificed afterwards and the hearts explanted. The Cardioband™ was found to be adequately implanted in all animals, with no anchor dehiscence and no damage of the circumflex artery (CX) or the coronary sinus (CS). The correct length of the band as chosen according to the length of the posterior mitral annulus measured in CT before implantation was confirmed in gross examination in all animals. The device did not result in a metal artifact-related degradation of image quality. The closest distance from the closest anchor to the CX was 2.1 ± 0.7 mm in diastole and 1.6 ± 0.5 mm systole. Mitral annulus distance to the CS was 6.4 ± 1.3 mm in diastole and 7.7 ± 1.1 mm in systole. CT visualization and measurement of the mitral valve annulus dimensions is feasible and can become the imaging method of choice for procedure planning of Cardioband™ implantations or other transcatheter mitral annuloplasty devices.

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Abbreviations

CT:

Computed tomography

CX:

Circumflex artery

ECG:

Electrocardiogram

FoV:

Field of view

ICE:

Intracardiac echocardiography

IVC:

Inferior vena cava

MR:

Mitral valve regurgitation

MVR:

Mitral valve repair

SAFIRE:

Sinogram-affirmed iterative reconstruction

TAVI:

Transcatheter aortic valve implantation

TSchG:

Swiss Animal Protection Law

TSchV:

Swiss Animal Protection Act

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Acknowledgments

We want to thank Tal Sheps (Valtech Cardio) for his support and valuable input in this study.

Conflict of interest

Volkmar Falk and Francesco Maisano are consultants for Valtech Cardio.

Author information

Authors and Affiliations

  1. Division of Cardiovascular Surgery, University Hospital Zurich, Zurich, Switzerland

    Simon H. Sündermann, Volkmar Falk & Francesco Maisano

  2. Institute of Diagnostic and Interventional Radiology, University Hospital Zurich, Zurich, Switzerland

    Sonja Gordic, Robert Manka & Hatem Alkadhi

  3. Clinic of Cardiology, University Hospital Zurich, Zurich, Switzerland

    Robert Manka

  4. Institute for Biomedical Engineering, University and ETH Zurich, Zurich, Switzerland

    Robert Manka

  5. Department of Surgical Research, University Hospital Zurich, Zurich, Switzerland

    Nikola Cesarovic

Authors
  1. Simon H. Sündermann
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  2. Sonja Gordic
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  3. Robert Manka
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  4. Nikola Cesarovic
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  5. Volkmar Falk
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  6. Francesco Maisano
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  7. Hatem Alkadhi
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Corresponding author

Correspondence to Hatem Alkadhi.

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Sündermann, S.H., Gordic, S., Manka, R. et al. Computed tomography for planning and postoperative imaging of transvenous mitral annuloplasty: first experience in an animal model. Int J Cardiovasc Imaging 31, 135–142 (2015). https://doi.org/10.1007/s10554-014-0516-7

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  • DOI: https://doi.org/10.1007/s10554-014-0516-7

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