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Effect of blood donation-mediated volume reduction on regional right ventricular deformation in healthy subjects

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Abstract

Strain (S) and strain rate (SR) are known to be altered in diseases associated with right ventricular (RV) pressure/volume overload and RV myocardial dysfunction; however determinants of S/SR are incompletely understood. The aim of this study was to examine the effect of blood donation-mediated volume reduction on regional RV deformation in healthy young adults. Study population was composed of 61 consecutive healthy subjects who were volunteers for blood donation. All underwent standard echocardiography and two-dimensional S and SR imaging by speckle tracking before and after 450 mL blood donation. We found no change in RV lateral wall SR in all three segments. However, the S in the apical and mid segments of the RV lateral wall immediately decreased after blood donation [−26.2 ± 3.3 vs. −23.2 ± 3.3 % (p < 0.0001) and −28.2 ± 3.4 vs. −27.1 ± 3.2 % (p = 0.009), respectively], whereas no change was observed in the basal segment. Moreover, changes in systolic S on the apical segment of the RV lateral wall before and after blood donation were significantly correlated with the changes in the RV size [end-diastolic area index, r = − 0.369 (p = 0.003) and end-systolic area index, r = − 0.319 (p = 0.012)] and changes in the stroke volume index [r = − 0.436 (p < 0.001)]. Blood donation-mediated volume reduction in healthy subjects caused a regional difference in RV longitudinal deformation with the lower mid and apical S that was related to parameters of volume load severity. However, RV systolic SR was found to be resistant to the effects of volume depletion.

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I (we) certify that there is no conflict of interest with any financial organization regarding the material discussed in the manuscript.

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Authors and Affiliations

  1. Department of Cardiology, Kartal Kosuyolu High Specialty Education and Research Hospital, Denizer Street, Cevizli Kavsagi, No: 2, Postal code: 34846, Kartal, Istanbul, Turkey

    Göksel Açar, Elnur Alizade, Anıl Avci, Hakan Çakir, Suleyman Çagan Efe, Mehmet Emin Kalkan, Mehmet Mustafa Tabakci, Cuneyt Toprak & Ali Metin Esen

  2. Department of Cardiology, Ataturk University School of Medicine, Erzurum, Turkey

    Ibrahim Halil Tanboğa

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  1. Göksel Açar
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  2. Elnur Alizade
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Correspondence to Göksel Açar.

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Açar, G., Alizade, E., Avci, A. et al. Effect of blood donation-mediated volume reduction on regional right ventricular deformation in healthy subjects. Int J Cardiovasc Imaging 30, 543–548 (2014). https://doi.org/10.1007/s10554-014-0375-2

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  • DOI: https://doi.org/10.1007/s10554-014-0375-2

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