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Global and regional wall motion abnormalities of pacing-induced heart failure assessed by multi-detector row CT: a patient and canine model study

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Abstract

This study used multi-detector row CT (MDCT) to evaluate the regional geometric parameters of left ventricle (LV) in patients and dogs after right ventricular apical (RVA) pacing. First, we measured and compared the global and regional wall motion parameters derived from MDCT images between three patients post RVA pacing and seven age-matched healthy subjects. The LV ejection fraction (LVEF), LV end-diastolic volume and LV end-systolic volume were measured. We also measured the regional wall thickness, wall thickening and regional wall motion in 12 different segments of the LV. Second, we performed MDCT scan on five dogs as the study group (pacing wire + RVA pacing, 2 months) and four dogs as the sham control group (pacing wire, 2 months). The global and regional geometric parameters were compared within both human and canine groups. Compared with normal subjects, patients post RVA pacing had low LVEF (60.4 ± 10.5 vs. 33.2 ± 17.6, P = 0.014), impaired regional wall thickening and regional wall motion, particularly in segments near the pacing lead. Some segments near the pacing lead were showing dyskinesia after pacing. These findings were successfully reproduced in the canine model. We found that RVA pacing can result in impaired regional wall thickening and regional wall motion, particularly in segments near the pacing lead.

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Acknowledgments

Supported in part by grants from Taichung Veterans General Hospital (TCVGH-973106C, 983105C, 983104B, 975506C, and 985506C), Yen Tjing Lin Medical Foundation (CI 97-12) and the National Science Council (NSC 96-2314-B-075A-011, 97-2314-b-075A-012).

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Authors and Affiliations

  1. Department of Radiology, Taichung Veterans General Hospital, Taichung, Taiwan

    I-Chen Tsai, Wan-Chun Liao, Min-Chi Chen, Wei-Lin Tsai & Clayton Chi-Chang Chen

  2. Faculty of Medicine and Institute of Clinical Medicine, National Yang Ming University, Taipei, Taiwan

    I-Chen Tsai, Jin-Long Huang, Wei-Lin Tsai, Yun-Ching Fu & Chih-Tai Ting

  3. Cardiovascular Center, Taichung Veterans General Hospital, No. 160, Sec. 3, Taichung Harbor Road, 407, Taichung, Taiwan

    Jin-Long Huang, Chin-Fang Hung, Ho-Yi Lei & Chih-Tai Ting

  4. Division of Cardiology and Cardiovascular Research Group, Institute of Medicine, Chung-Shan Medical University Hospital, Taichung, Taiwan

    Jin-Long Huang & Kwo-Chang Ueng

  5. Department of Education and Research, Taichung Veterans General Hopsital, Taichung, Taiwan

    Yi-Wen Hung

  6. Department of Radiological Technology and Institute of Radiological Science, Central Taiwan University of Science and Technology, Taichung, Taiwan

    Wan-Chun Liao, Min-Chi Chen & Clayton Chi-Chang Chen

  7. Division of Cardiology, Taipei Veterans General Hospital, Taipei, Taiwan

    Shih-Ann Chen

  8. Department of Physical Therapy and Assistive Technology, National Yang Ming University, Taipei, Taiwan

    Clayton Chi-Chang Chen

  9. Division of Pediatric Cardiology, Department of Pediatrics, Taichung Veterans General Hospital, Taichung, Taiwan

    Yun-Ching Fu

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  1. I-Chen Tsai
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  2. Jin-Long Huang
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  3. Kwo-Chang Ueng
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  4. Yi-Wen Hung
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  5. Chin-Fang Hung
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  8. Min-Chi Chen
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  9. Wei-Lin Tsai
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  10. Shih-Ann Chen
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  11. Clayton Chi-Chang Chen
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  12. Yun-Ching Fu
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  13. Chih-Tai Ting
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Corresponding author

Correspondence to Jin-Long Huang.

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Tsai, IC., Huang, JL., Ueng, KC. et al. Global and regional wall motion abnormalities of pacing-induced heart failure assessed by multi-detector row CT: a patient and canine model study. Int J Cardiovasc Imaging 26 (Suppl 2), 223–235 (2010). https://doi.org/10.1007/s10554-010-9684-2

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  • DOI: https://doi.org/10.1007/s10554-010-9684-2

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